4679-90-7

Usage

Appearance

White to light yellow solid at room temperature

Derivative of

Isatin

Potential pharmacological activities

+ Monoamine oxidase inhibitor (useful in the treatment of depression and other mood disorders)
+ Anticonvulsant properties
+ Analgesic properties

Need for further studies

To fully understand the potential therapeutic applications of the compound.

Upstream product

• 86770-00-5 (E)-N-phenyl-2-styrylbenzamide 
• 907174-66-7 C₁₅H₁₁ClO 
• 62-53-3 aniline 
• 60901-21-5 o-styrylbenzoic acid 
• 63104-88-1 Methyl 2-styrylbenzoate 
• 100-42-5 styrene 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 82971-74-2 N-phenyl-2-(2-phenylethynyl)benzamide 
• 15310-01-7 benodanil 
• 82971-76-4 (Z)-2-phenyl-3-(phenylmethylene)isoindolin-1-one 

Relevant academic research and scientific papers

Novel synthetic method of 3,4-dihydroisoquinolin-1-one and isoindolin-1-one derivatives

The invention relates to a synthetic method of 3,4-dihydroisoquinolin-1-one and isoindolin-1-one derivatives; particularly, a base is added to 2-allyl-benzamide serving as a raw material under the protection of nitrogen, and heating is performed in a solvent to obtain dihydroisoquinolin-1-one or isoindolin-1-one compounds under high yield. The synthetic method is simple to perform, high in reaction yield and low in usage of bases in reaction, has no need for using transition metal catalysts, and is highly worthy of application in the industrial preparation of isoindolin-1-one compounds.

Intramolecular Hydroamidation of ortho-Vinyl Benzamides Promoted by Potassium tert-Butoxide/N,N-Dimethylformamide

An intramolecular hydroamidation of ortho-vinyl benzamides had been developed. The reaction was promoted efficiently by potassium tert-butoxide and N,N-dimethylformamide without the need for strong oxidants or transition-metal catalysts. A series of dihyd

Novel chemoselective desulfurization of γ-phenylthio-substituted aromatic lactams: Application to the synthesis of isoindolobenzazepine alkaloid, lennoxamine

Treatment of a variety of γ-phenylthio-substituted aromatic lactams with lithium aluminum hydride in the presence of cuprous iodide led to novel chemoselective desulfurization reactions to afford the corresponding substituted aromatic lactams without givi

Palladium-catalysed heteroannulation with terminal alkynes: A highly regio- and stereoselective synthesis of (Z)-3-aryl(alkyl)idene isoindolin-1- ones

A highly regio- and stereoselective method for the synthesis of (Z)-3- aryl(alkyl)idene isoindolin-1-ones through palladium-copper catalysis is described. 2-Iodobenzamide 1 and its substituted derivatives 2-10 were reacted with terminal alkynes 11-19 in the presence of (PPh3)2PdCl2, CuI, and Et3N in DMF mostly at 80°C for 16 h to yield the 2-alkynyl substituted benzamides 20-38, 40-45, 77 which could then be cyclised with NaOEt in EtOH to the 3-aryl(alkyl)idene isoindolin-1-ones 46-49, 51, 53-55, 57, 59-71, 73 and 75. In certain cases, the isoindolin-1-ones 50, 52, 56 and 58 could be directly obtained by the palladium-catalysed reactions. (C) 2000 Elsevier Science Ltd.