83-39-6

Usage

Uses

Used in Pharmaceutical Industry:
Imidazole-4,5-dicarboxamide is used as a chemical intermediate for the synthesis of various pharmaceutical drugs. Its unique structure and properties make it a valuable component in the development of medications for a broad spectrum of treatments.
Used in Research and Development:
Imidazole-4,5-dicarboxamide serves as a key compound in various research and development applications. Its potential use in biological studies allows scientists to explore its properties and applications further, contributing to the advancement of scientific knowledge and potential new drug discoveries.
Used in Chemical Synthesis:
Due to its unique structure and properties, Imidazole-4,5-dicarboxamide is utilized in the synthesis of other chemical compounds. Its versatility in chemical reactions makes it a valuable component in the creation of new materials and products across various industries.

InChI:InChI=1/C5H6N4O2/c6-4(10)2-3(5(7)11)9-1-8-2/h1H,(H2,6,10)(H2,7,11)(H,8,9)

Upstream product

• 1122-28-7 4,5-dicyano-1H-imidazole 
• 3304-70-9 dimethyl imidazole-4,5-dicarboxylate 
• 124-41-4 sodium methylate 
• 570-22-9 4,5-imidazoledicarboxylic acid 

Downstream Products

• 69-89-6 xanthin 
• 66678-51-1 1-(β-D-Ribofuranosyl)imidazol-4,5-dicarboxamid 

Relevant academic research and scientific papers

Derivatives of 1H-imidazole-4,5-dicarboxamide and Use Thereof in Preparation of Anticoccidial Drugs

Disclosed are derivatives of 1H-imidazole-4,5-dicarboxamide and use thereof in preparation of anticoccidial drugs. The derivatives have structural formulae as shown in formulae (I) to (VI). The derivatives of 1H-imidazole-4,5-dicarboxamide as disclosed in the present invention have significant anticoccidial effect, especially against coccidia that show a resistance to other anticoccidial drugs, and thus they can be used in preparation of anticoccidial drug.

A Green One-Pot Synthesis of vic -Amidino (Hetero)aromatic Acids from 1,2-Dinitriles

Phthalonitrile undergoes partial hydration in MeOH-H2O media in the presence of an equimolar amount of NaOH to afford 2-carbamimidoylbenzoic acid in good yield in one step. This and similar vic-amidino (hetero)aromatic acids also could be synthesized from corresponding 1,2-dinitriles by hydrolysis in aqueous MeOH catalyzed by an equimolar amount of NaOH of in situ generated 1,1-dimethoxy-1H-isoindol-3-amine or its counterparts. Protonation of the synthesized amidino acids, esterification, and reamination of the parent amidino benzoic acid with N-nucleophiles were performed.