83133-17-9

Usage

Uses

Used in Pharmaceutical Industry:
4',5-Dihydroxy-3',5',6,7-tetramethoxyflavone is used as a therapeutic agent for its potential in treating cardiovascular diseases, neurodegenerative disorders, and cancer due to its antioxidant, anti-inflammatory, and anti-cancer properties.
Used in Nutraceutical Industry:
In the nutraceutical industry, 4',5-Dihydroxy-3',5',6,7-tetramethoxyflavone is used as a dietary supplement for its health-promoting properties, including its ability to protect cells from oxidative damage and reduce inflammation.
Used in Cosmetic Industry:
4',5-Dihydroxy-3',5',6,7-tetramethoxyflavone is used as an ingredient in cosmetic products for its antioxidant and anti-inflammatory effects, which can contribute to skin health and protection against environmental stressors.
Used in Research and Development:
In the field of research and development, 4',5-Dihydroxy-3',5',6,7-tetramethoxyflavone is utilized for studying its potential as a therapeutic agent and exploring its mechanisms of action in various health-related applications.

Upstream product

• 93124-90-4 4'-hydroxy-3',5,5',6,7-pentamethoxyflavone 
• 14588-61-5 4-benzyloxy-3,5-dimethoxybenzoic acid chloride 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 642-71-7 3,4,5-trimethoxyphenol 
• 6527-32-8 4-(benzyloxy)-3,5-dimethoxybenzaldehyde 
• 89354-96-1 2-(3',5'-dimethoxy-4'-benzyloxy)benzoyloxy-4,5,6-trimethoxyacetophenone 
• 89354-97-2 2-hydroxy-4'-benzyloxy-3',4,5,5',6-pentamethoxydibenzoylmethane 
• 14588-60-4 4-(benzyloxy)-3,5-dimethoxybenzoic acid 
• 22248-14-2 6-hydroxy-2,3,4-trimethoxyacetophenone 
• 89354-95-0 4'-benzyloxy-5,6,7,3',5'-pentamethoxyflavone 

Downstream Products

• 89354-99-4 5,4'-di-O-acetyl-6,7,3',5'-tetramethoxyflavone 

Relevant academic research and scientific papers

Synthesis and anti-proliferative activities of 5,6,7-trimethoxyflavones and their derivatives

A series of 5,6,7-trimethoxyflavones 1a-1g and their derivatives 2a-2g, 3a-3d, 4 and 5, including the natural products 5,6,7-trimethoxy-4’-hydroxyflavone (1a), 5,6,7,3’,4’ -pentamethoxyflavone (sinensetin, 1 b), 5,6,7-trimethoxy-3’,4’-methyl enedioxy flavone (1c), 5,6,7,3’-tetramethoxy-4,5’-methylenedioxyflavone (1e), 5,6,7, 3’,4’,5’-hextamethoxyflavone (1 g), 5-hydroxy-3,4,2’,3’,4’-pentamethoxy chal-cone (2 b), 5,4’-dihydroxy-6,7-dimethoxy flavone (cirsimaritin, 3a) and 5-hydroxy-6,7,3’, 4’-tetramethoxyflavone (5-demethylsinensetin, 3 b), 3,5,6,7,3’,4’-hexamethoxyflavone (3-methoxysinensetin, 4) and 5’-hydroxy-3,6,7,3’,4’-pentamethoxyflavone (5) were synthesized. Their anti-proliferative activity in?vitro was evaluated against a panel of four human cancer cell lines (Aspc-1, HCT-116, HepG-2 and SUN-5) by the CTG assay. The results showed that most of the synthetic compounds exhibited moderate to high anti-proliferative activities. In particular, compound 3c possess IC50 (5.30 μM) values below 10 μM against Aspc-1 cells and are worthy of further investigation.

Synthetic Studies on the Flavone Derivatives. XII. Synthesis of 2',3',5'- and 3',4',5'-Trioxygenated Flavones

Two unusual flavones, 5,5'-dihydroxy-2',3',6,7-tetramethoxyflavone (1) from Gardenia cramerii and 4',5-dihydroxy-3',5',6,7-tetramethoxyflavone (6) from Artemisia mesatlantia, and their position isomers were synthesized to investigate the structural correlation in terms of spectral data.The structure of the flavone from G. cramerii is discussed.Keywords: 5,5'-dihydroxy-2',3',6,7-tetramethoxyflavone; 2',5-dihydroxy-3',5',6,7-tetramethoxyflavone; 5-hydroxy-2',3',5',6,7-pentamethoxyflavone; 3',5-dihydroxy-4',5',6,7-tetramethoxyflavone; 4',5-dihydroxy-3',5',6,7-tetramethoxyflavone; 5-hydroxy-3',4',5',6,7-pentamethoxyflavone.

Constitution of Artemisia mesatlantica Pigment: A Synthetic Study

Synthesis of 5,4'-dihydroxy-6,7,3',5'-tetramethoxyflavone (1) using 4'-benzyloxy-5,6,7,3',5'-pentamethoxyflavone (2) as the key-intermediate is described.The synthetic (1) differs from the natural sample isolated from Artemisia mesatlantica Phytochemistr