83190-03-8Relevant articles and documents
QUINAZOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
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Paragraph 0219; 0220, (2017/07/14)
Disclosed are a quinazoline derivative, a preparation method therefor, and a pharmaceutical composition and an application thereof. The present invention provides a compound represented by general formula I, a stereoisomer thereof and a pharmaceutical acceptable salt or a solvate thereof. The quinazoline derivative of the present invention has a unique chemical structure, is characterized by irreversibly inhibiting EGFR tyrosine kinase, has high biological activity, apparently improves the inhibiting effect on the EGFR tyrosine kinase, has quite strong tumor inhibiting effect on tumor cells and a transplantation tumor pathological model of animal tumors, and has good market developing prospects.
Regioselective fluoroalkoxylation and polyfluoroalkoxylation of aromatic and heteroaromatic polyhalides
Gupton, John T.,Hertel, George,DeCrescenzo, Gary,Colon, Cesar,Baran, Donna,et al.
, p. 3037 - 3042 (2007/10/02)
A series of activated polyhalobenzenes and polyhaloheteroaromatic compounds have been reacted with a variety of fluoroalkoxide anions.In most cases, regioselective monosubstitution or polysubstitution was observed.The nature of these monosubstitution and polysubstitution reactions is described.