832-65-5Relevant academic research and scientific papers
Formylation of electron-rich aromatic rings mediated by dichloromethyl methyl ether and TiCl4: Scope and limitations
Ramos-Tomillero, Iván,Paradís-Bas, Marta,De Pinho Ribeiro Moreira, Ibério,Bofill, Josep María,Nicolás, Ernesto,Albericio, Fernando
supporting information, p. 5409 - 5422 (2015/05/13)
Here the aromatic formylation mediated by TiCl4 and dichloromethyl methyl ether previously described by our group has been explored for a wide range of aromatic rings, including phenols, methoxy- and methylbenzenes, as an excellent way to produce aromatic aldehydes. Here we determine that the regioselectivity of this process is highly promoted by the coordination between the atoms present in the aromatic moiety and those in the metal core.
Synthesis of polyalkoxy-3-(4-methoxyphenyl)coumarins with antimitotic activity from plant allylpolyalkoxybenzenes
Tsyganov, Dmitry V.,Chernysheva, Natalia B.,Salamandra, Lev K.,Konyushkin, Leonid D.,Atamanenko, Olga P.,Semenova, Marina N.,Semenov, Victor V.
, p. 147 - 149 (2013/07/26)
Novel polyalkoxy-3-(4-methoxyphenyl)coumarins - analogues of natural antimitotic compounds - were synthesized from plant allylpolyalkoxybenzenes and tested in vivo in the phenotypic sea urchin embryo assay for antiproliferative antitubulin activity.
o-Formylation of electron-rich phenols with dichloromethyl methyl ether and TiCl4
García, Oscar,Nicolás, Ernesto,Albericio, Fernando
, p. 4961 - 4963 (2007/10/03)
o-Formylation of electron-rich phenols is accomplished with dichloromethyl methyl ether and TiCl4. The reaction gives excellent yields, good regioselectivity, and does not leading to diformylation.
Synthesis of 5,6'-Dihydroxy-6,7,2',3',4'-pentamethoxyflavone: Revision of Structure of Brickellin
Malhotra, Sunita,Sharma, V. K.,Gupta, S. R.,Parmar, V. S.
, p. 59 - 60 (2007/10/02)
5,6'-Dihydroxy-6,7,2',3',4'-pentamethoxyflavone (I), the constitution proposed for brickellin, a new highly oxygenated flavone isolated from Brickellia veronicaefolia and B. chlorolepsis (Phytochemistry 34 163) has been synthesised.The spectral dat
SYNTHESIS OF 5,6'-dihydroxy-2',3',4',6,7-PENTAMETHOXYFLAVONE
Iinuma, Munekazu,Iwashima, Kiyoshi,Tanaka, Toshiyuki,Matsuura, Shin
, p. 4217 - 4219 (2007/10/02)
5,6'-Dihydroxy-2',3',4',6,7-pentamethoxy- (1), 2',5-dihydroxy-3',4',6,6',7-pentamethoxy- (2) and 3',5-dihydroxy-2',4',6,6',7-pentamethoxyflavone (3) were synthesized to compare with brickellin isolated from Brickellia veronicaefolia and B. chlorolepis.The
