83256-99-9

Basic information

• Product Name: methyl 3-(3-nitrophenyl)-3-oxopropanoate
• CAS NO: 83256-99-9
• Molecular Formula: C₁₀H₉NO₅
• Molecular Weight: 223.1822
• Mol File: 83256-99-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 298.9°C at 760 mmHg
• Flash Point: 127.2°C
• Density: 1.318g/cm³
• Vapor Pressure: 0.00124mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: methyl 3-(3-nitrophenyl)-3-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(3-nitrophenyl)-3-oxopropanoate(83256-99-9)
• EPA Substance Registry System: methyl 3-(3-nitrophenyl)-3-oxopropanoate(83256-99-9)

Safety Data

• Hazardous Substances Data: 83256-99-9(Hazardous Substances Data)

Usage

General Description

Methyl 3-(3-nitrophenyl)-3-oxopropanoate, also known as methyl 3-(3-nitrophenyl)pyruvate, is a chemical compound with the molecular formula C10H9NO6. It is a nitrophenyl derivative of pyruvic acid and belongs to the class of organic compounds known as nitrophenylpyruvates. methyl 3-(3-nitrophenyl)-3-oxopropanoate is commonly used as a precursor in the synthesis of various pharmaceuticals and organic compounds. It is also used in organic chemical reactions and research. Methyl 3-(3-nitrophenyl)-3-oxopropanoate is a yellow to orange solid with a characteristic odor. It is important to handle this chemical with care as it is potentially hazardous and should be used in a well-ventilated area and with proper safety precautions.

Upstream product

• 79-20-9 acetic acid methyl ester 
• 618-98-4 ethyl 3-nitrobenzoate 
• 141-78-6 ethyl acetate 
• 4996-15-0 3-(3-nitrophenyl)propynoic acid 
• 99-61-6 3-nitro-benzaldehyde 
• 6832-16-2 methyl diazoacetate 
• 932-90-1 syn-benzaldehyde oxime 
• 7515-22-2 methyl 3-(3-nitrophenyl)propiolate 

Downstream Products

• 103029-79-4 3-(3-nitrophenyl)isoxazol-5(4H)-one 
• 181057-91-0 3-(3-nitrophenyl)-5-chloroisoxazole 

Relevant articles and documents

METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF

Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

Structure-activity studies of a series of dipyrazolo[3,4-b:3′,4′-d]pyridin-3-ones binding to the immune regulatory protein B7.1

The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases. To this end, specific small molecule inhibitors of human B7.1 were identified and characterized. Herein, we report the identification of potent small molecule inhibitors of the B7.1-CD28 interaction. In a high-throughput screen we identified several leads that prevented the interaction of B7.1 with CD28 with activities in the nanomolar to low micromolar range. One of these, the dihydrodipyrazolopyridinone 1, was subsequently shown to bind the V-like domain of human B7.1 at equimolar stoichiometry. With this as a starting point, we report here the synthesis and initial in vitro structure-activity relationships of a series of these compounds.

Color photographic recording material

The present invention relates to new compounds having an active methylene group or phenolic hydroxyl group and therefore capable of being used as photographic color couplers. The new compounds contain at least one radical of a phosphoric acid diester, phosphonic acid diester, phosphoric acid diamide, phosphonic acid diamide, phosphoric acid ester-amide or phosphonic acid ester-amide.