83256-99-9

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 3-(3-nitrophenyl)-3-oxopropanoate is used as a precursor for the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows it to be a key component in the development of new drugs and medications.
Used in Organic Chemical Reactions:
In the field of organic chemistry, methyl 3-(3-nitrophenyl)-3-oxopropanoate is utilized in a variety of chemical reactions. Its reactivity and functional groups make it a valuable intermediate for the synthesis of complex organic molecules.
Used in Research:
Methyl 3-(3-nitrophenyl)-3-oxopropanoate is also used in research settings to study the properties and reactions of nitrophenylpyruvates. This helps scientists to better understand the behavior of these compounds and to develop new methods and applications for their use.
It is important to handle this chemical with care as it is potentially hazardous and should be used in a well-ventilated area and with proper safety precautions.

Upstream product

• 932-90-1 syn-benzaldehyde oxime 
• 7515-22-2 methyl 3-(3-nitrophenyl)propiolate 
• 618-98-4 ethyl 3-nitrobenzoate 
• 141-78-6 ethyl acetate 
• 4996-15-0 3-(3-nitrophenyl)propynoic acid 
• 99-61-6 3-nitro-benzaldehyde 
• 6832-16-2 methyl diazoacetate 
• 79-20-9 acetic acid methyl ester 

Downstream Products

• 181057-91-0 3-(3-nitrophenyl)-5-chloroisoxazole 
• 103029-79-4 3-(3-nitrophenyl)isoxazol-5(4H)-one 

Relevant academic research and scientific papers

METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF

Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

Synthesis of β-Keto Esters Promoted by Yttria-Zirconia Based Lewis Acid Catalyst

A variety of aldehydes react with methyl/ethyl diazoacetate in the presence of yttria-zirconia based catalyst to afford the corresponding β-keto esters in excellent yields.

Structure-activity studies of a series of dipyrazolo[3,4-b:3′,4′-d]pyridin-3-ones binding to the immune regulatory protein B7.1

The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases. To this end, specific small molecule inhibitors of human B7.1 were identified and characterized. Herein, we report the identification of potent small molecule inhibitors of the B7.1-CD28 interaction. In a high-throughput screen we identified several leads that prevented the interaction of B7.1 with CD28 with activities in the nanomolar to low micromolar range. One of these, the dihydrodipyrazolopyridinone 1, was subsequently shown to bind the V-like domain of human B7.1 at equimolar stoichiometry. With this as a starting point, we report here the synthesis and initial in vitro structure-activity relationships of a series of these compounds.

Color photographic recording material

The present invention relates to new compounds having an active methylene group or phenolic hydroxyl group and therefore capable of being used as photographic color couplers. The new compounds contain at least one radical of a phosphoric acid diester, phosphonic acid diester, phosphoric acid diamide, phosphonic acid diamide, phosphoric acid ester-amide or phosphonic acid ester-amide.