832754-48-0

Upstream product

• 79280-92-5 (3-fluoro-4-hydroxy-phenyl)-acetic acid methyl ester 
• 100-39-0 benzyl bromide 
• 452-14-2 2-(4-fluoro-3-methoxyphenyl)acetic acid 
• 458-09-3 (3-fluoro-4-hydroxyphenyl)acetic acid 
• 404-90-0 2-(3-fluoro-4-methoxyphenyl)acetonitrile 
• 351-52-0 3-fluoro-4-methoxybenzyl chloride 
• 321-28-8 1-fluoro-2-methoxybenzene 
• 620-05-3 iodomethylbenzene 

Downstream Products

• 832754-49-1 2-(4-benzyloxy-3-fluoro-phenyl)-ethanol 
• 127414-05-5 [4-(benzyloxy)-3-fluorophenyl]acetic acid 

Relevant academic research and scientific papers

TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO

The present invention relates to certain trisubstituted aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.

USE OF QSAR IN DESIGN OF ANTIINFLAMMATORY FLUORINATED ARYLALKANOIC ACIDS

A series of 3-fluoro-4-alkoxyphenylalkanoic acids III was synthetized and their antiinflammatory activity and fibrinolytic capacity was evaluated.The suitable fluorinated derivative with better pharmacological profile than 3-chloro-4-benzyloxyphenylacetic acid (benzofenac) was selected.Experimental, biological activities of acids III were compared with those calculated by introducing the physico-chemical parameters into the formerly derived regression equations.Good coincidence was found out, as well as similarity of the regression equations derived for the originalseries of acids extended by the acids III.Lipophilicity of the acids under study was evaluated by partition thin-layer chromatography; the values of log P of benzyloxy derivatives IIIc-IIIf were lower than tabulated values - probably due to the intramolecular hydrophobic interactions of aromatic nuclei.