83300-84-9

Upstream product

• 141-97-9 ethyl acetoacetate 
• 100-52-7 benzaldehyde 
• 292638-85-8 acrylic acid methyl ester 
• 62-53-3 aniline 
• 104-94-9 4-methoxy-aniline 
• 123-11-5 4-methoxy-benzaldehyde 
• 67-56-1 methanol 
• 83300-83-8 diethyl 1,4-bis(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 83300-81-6 diethyl 1-phenyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant academic research and scientific papers

Palladium-assisted multicomponent cyclization of aromatic aldehydes, arylamines and terminal olefins under molecular oxygen: An assembly of 1,4-dihydropyridines

The palladium-assisted one-pot three-component reactions of aldehydes, amines and olefins proceeded smoothly to give 2,6-unsubstituted 1,4-dihydropyridines (1,4-DHPs) using molecular oxygen as a sole oxidant. It also provides efficient Pd-catalyzed aerobic oxidation access to the anti-Markovnikov oxidative amination products of olefins from primary aromatic amines and alkenes. The method is atom-efficient, using cheap and easily available starting materials and an environmentally benign oxidant.

EFFECT OF SUBSTITUENTS IN THE DIHYDROPYRIDINE RING ON THE REACTIVITY OF THE ESTER GROUP OF 3,5-DIALKOXYCARBONYL-1,4-DIHYDROPYRIDINES

The reactivity of the ester group of 3,5-dialkoxycarbonyl-1,4-dihydropyridines upon reaction with nucleophilic reagents increases when substituents are absent in the ortho positions relative to the ester group and also in the case of steric disruption of the coplanarity of the β-aminovinylcarbonyl system when substituents are introduced at the nitrogen atom in 2,6-dimethyl derivatives.Mono- and dicarboxylic acids were obtained by hydrolysis of such esters.Thus use of esters of propiolic acid esters and arylamines in the Hantzsch synthesis made it possible to obtain 1-aryl-2,6-unsubstituted derivatives of 1,4-dihydropyridine.