Efficient preparation of ((3-chloro-2-fluorophenyl)-[7-methoxy-8-(3- morpholin-4-yl-propoxy)-10,11-dihydro-5-oxa-2,4,11-triazadibenzo(a,d) cyclohepten-1-yl]-amine) for in-vivo study

Article abstract of DOI:10.1080/00397910500377479

An improved route for the preparation of highly functionalized 5,6-dihydropyrimido[4,5-b][1,4]oxazepine 1a in multigram quantities was developed. This new methodology was highlighted by the proper methoxy disposition via a regioselective methylation of 2,4,5-trihydroxy-benzaldehyde followed by a magnesium sulfate-promoted cyclization. Copyright Taylor & Francis LLC.