83408-17-7

Upstream product

• 52317-51-8 p-Toluyl-p-toluylthiomethylsulfoxid 
• 98-88-4 benzoyl chloride 
• 93-89-0 benzoic acid ethyl ester 
• 59532-35-3 (+)-(S)-4-Methylphenyl 4-methylphenylthiomethyl sulfoxide 

Downstream Products

• 78549-06-1 1-phenyl-2-p-tolylthio-2-p-tolylsulphinylethanol 
• 78549-08-3 (1S,2S,3S)-1-phenyl-2-p-tolylthio-2-p-tolylsulphinylethanol 
• 78549-07-2 (1R,2R,3S)-1-phenyl-2-p-tolylthio-2-p-tolylsuphinylethanol 
• 83461-62-5 1-phenyl-2-p-tolylthio-2-p-tolylsulphinylethanol 

Relevant academic research and scientific papers

Asymmetric Synthesis of Protected α-Hydroxyaldehydes via Reduction of α-Arylthio-β-oxosulphoxides

The complex metal hydride reduction of α-arylthio-β-oxosulphoxides to the corresponding alcohols is highly stereospecific.The stereochemical course of the reaction has been determined and a detailed examination of the factors responsible for the stereospe

AN EFFICIENT 1,3-ASYMMETRIC INDUCTION ACCOMPANIED WITH EPIMERIZATION AT THE 2-POSITION. STEREOSELECTIVE REDUCTION OF α-SUBSTITUTED β-KETO SULFOXIDES UNDER BASIC CONDITIONS

An efficient 1,3-asymmetric induction was realized in the reduction of β-keto sulfoxides having various α-substituents with NaBH4 under basic conditions and, by the application of this induction, (R)-α-acetoxyphenylacetaldehyde was synthesized.

ASYMMETRIC SYNTHESIS OF PROTECTED α-HYDROXYALDEHYDES FROM ACYL CHLORIDES USING p-TOLYL p-TOLYLTHIOMETHYL SULFOXIDE AS CHIRAL CARBONYL SYNTHON

Carbonyl protected α-hydroxyaldehydes 3 were obtained in high diastereomeric purity through LiAlH4 reduction of corresponding β-sulfoxides 2 prepared via acylation of p-tolyl p-tolylthiomethyl sulfoxide 1.