83544-55-2Relevant articles and documents
Transannular rearrangement of activated 2,5-diketopiperazines: A key route to original scaffolds
Farran, Daniel,Parrot, Isabelle,Toupet, Loic,Martinez, Jean,Dewynter, Georges
experimental part, p. 3989 - 3996 (2009/06/28)
An efficient and original stereocontrolled transannular rearrangement starting from activated 2,5-diketopiperazines has been developed, an opportunity for the medicinal chemistry field, which requests access to novel biological scaffolds. This powerful ri
Acylaminoacetyl Derivatives of Active Methylene Compounds. 3. C-Acylation Reactions via the Hippuric Acid Azlactone
Hamilakis, Stylianos,Kontonassios, Demetrios,Sandris, Constantine
, p. 1145 - 1150 (2007/10/02)
The C-acylation reactions of the active methylene compounds, methyl cyanoacetate and Meldrum's acid, with hippuric acid, using the DCC activation and the mixed anhydride conditions, are shown to proceed through initial formation of 2-phenyl-5(4H)oxazolone, the hippuric acid azlactone.The conditions of these reactions using the azlactone as the acylating agent were investigated and discussed.