83544-55-2Relevant academic research and scientific papers
Transannular rearrangement of activated 2,5-diketopiperazines: A key route to original scaffolds
Farran, Daniel,Parrot, Isabelle,Toupet, Loic,Martinez, Jean,Dewynter, Georges
experimental part, p. 3989 - 3996 (2009/06/28)
An efficient and original stereocontrolled transannular rearrangement starting from activated 2,5-diketopiperazines has been developed, an opportunity for the medicinal chemistry field, which requests access to novel biological scaffolds. This powerful ri
A kinetic study of the base-catalyzed dimerization of 5(4H)-oxazolones
Mazurkiewicz,Pierwocha,Fryczkowska
, p. 113 - 121 (2007/10/03)
The effects of the substituent at position-2 and kind of the base on the rate of the base-catalyzed dimerization of 5(4H)-oxazolones have been investigated. The electrondonating and strong steric effect of the substituent at position-2 reduce markedly the proclivity of 5(4H)-oxazolones to dimerization. The following catalytic activity sequence of the bases has been found: DBU >> Et3N > (i-Pr)2EtN.
Acylaminoacetyl Derivatives of Active Methylene Compounds. 3. C-Acylation Reactions via the Hippuric Acid Azlactone
Hamilakis, Stylianos,Kontonassios, Demetrios,Sandris, Constantine
, p. 1145 - 1150 (2007/10/02)
The C-acylation reactions of the active methylene compounds, methyl cyanoacetate and Meldrum's acid, with hippuric acid, using the DCC activation and the mixed anhydride conditions, are shown to proceed through initial formation of 2-phenyl-5(4H)oxazolone, the hippuric acid azlactone.The conditions of these reactions using the azlactone as the acylating agent were investigated and discussed.
Acylaminoacetyl Derivatives of Active Methylene Compounds. 1. The Cyclization of the Benzoylaminoacetyl Derivatives to α-Substituted Tetramic Acids (1)
Igglessi-Markopoulou, Olga,Sandris, Constantine
, p. 883 - 890 (2007/10/02)
Hippuric acid was converted to α-Y-substituted tetramic acids (Y = -CN, -CO2R and -COCH3) according to the following general scheme of reactions: a) preparation of the hippuric acid chloride or of its p-nitrophenyl ester; b) C-acylation of an active methy
