83640-72-6Relevant academic research and scientific papers
PEG-400 as a carbon synthon: Highly selective synthesis of quinolines and methylquinolines under metal-free conditions
Ding, Chengcheng,Feng, Kaili,Li, Shichen,Ma, Chen
, p. 5542 - 5548 (2021/08/16)
A metal-free, peroxide-free, and efficient procedure for the highly selective synthesis of quinolines and methylquinolines was reported. The main feature of this method was that the same substrate can produce quinolines and methylquinolines, respectively, under different reaction conditions. PEG-400 was used as both a reactant and solvent in this reaction. The utility of the designed procedure was also demonstrated by the derivatization of the products to bioactive compounds. This journal is
Method for synthesizing 2-hydrocarbylquinoline
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Paragraph 0046; 0047; 0050-0051; 0052; 0055, (2019/10/01)
The invention provides a method for synthesizing 2-hydrocarbylquinoline. The method comprises the following steps: heating and reacting aniline or substituted aniline, phenylacetylene or substituted phenylacetylene and montmorillonite in chlorobenzene, ad
One-pot synthesis of 2,4-disubstituted quinolines via silver-catalyzed three-component cascade annulation of amines, alkyne esters and terminal alkynes
Li, Yunlan,Zhang, Qiurui,Xu, Xuefeng,Zhang, Xu,Yang, Yurong,Yi, Wei
supporting information, p. 965 - 970 (2019/03/13)
Described herein is a new and general method for one-pot synthesis of 2,4-disubstituted quinolines via silver-catalyzed [3 + 1 + 2] annulation of simple amines, alkyne esters and terminal alkynes. The versatile transformation might initiate with the facil
A method for utilizing the aromatic amine, diketone synthesis of quinoline derivatives
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Paragraph 0033; 0034, (2018/02/04)
The invention provides a method for synthesizing quinoline by aromatic amine and diketone and belongs to the technical field of synthesis of the quinoline. According to the method for synthesizing the quinoline by the aromatic amine and the diketone, unde
Method for synthesizing quinoline derivative
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Paragraph 0100; 0101; 0102; 0103; 0104, (2017/02/28)
The invention provides a method for synthesizing a quinoline derivative. Aromatic amine, electrophilic alkyne and alkyne are sequentially added into a reaction vessel according to the molar ratio of 1:1:(1.2-4), solvent is added according to the proportion that 2-4 mL of solvent is added into 1 mmol of aromatic amine, then catalyst silver trifluoromethanesulfonate (AgOTf) with the molar weight being 0.8-5% that of aromatic amine and additive trifluoromethanesulfonic acid (HOTf) with the molar weight being 1.8-10% that of aromatic amine are added, reaction is conducted for 8-24 h at 100-120 DEG C in oil bath, the product is cooled to room temperature, water is added, the product is extracted three times with ethyl acetate, organic layers are combined, decompressive condensing is conducted, the product is subjected to column chromatography purification, and the product, namely the quinoline derivative, is obtained. The quinoline derivative has the advantages that reaction substrates are low in price, the yield is high, selectivity is good, separation and purification are easy, pollution is little, and steps are simple.
Silver-catalyzed one-step synthesis of multiply substituted quinolines
Xu, Xuefeng,Liu, Wenmin,Wang, Zhiqiang,Feng, Yuquan,Yan, Yanlei,Zhang, Xu
supporting information, p. 226 - 229 (2015/12/31)
A silver-catalyzed formation of C-C bond for the construction of a series of polysubstituted quinolines from arylamines, aldehydes, and ketones or arylamines and 1,3-diketones has been developed. The transformation is effective for a broad range of substrates, thus enabling the expansion of constituent architectures on the heterocyclic framework. This use of a single catalytic system to mediate chemical transformations in a synthetic operation is important for the development of new atom-economic strategies and this strategy is efficient in building complex structures from simple starting materials in an environmentally benign fashion.
The Reactions of Aromatic Schiff Bases with Dimethyl Acetylenedicarboxylate. I. Reaction in an Organic Solvent
Murphy, Shane T.,Taylor, Walter C.,Vadasz, Andrew
, p. 1215 - 1225 (2007/10/02)
Reaction of benzylideneanisidine with dimethyl acetylenedicarboxylate in refluxing xylene/nitrobenzene gave low yields of a bis-adduct, the dihydropyridine (12), and two dehydro adducts - the quinolines (13a) and (14).Anisylideneaniline under similar conditions gave the dihydropyridine (16) and an 'abnormal' bis-adduct.Benzylideneaniline gave only an 'abnormal' bis-adduct.
