142342-55-0

Basic information

• Product Name: METHANESULFONIC ACID 5-BOC-AMINO-PENTYL ESTER
• Synonyms: METHANESULFONIC ACID 5-BOC-AMINO-PENTYL ESTER;5-((tert-Butoxycarbonyl)aMino)pentyl Methanesulfonate
• CAS NO: 142342-55-0
• Molecular Formula: C₁₁H₂₃NO₅S
• Molecular Weight: 281.37
• Mol File: 142342-55-0.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 435.6°Cat760mmHg
• Flash Point: 217.2°C
• Appearance: /
• Density: 1.126g/cm³
• Vapor Pressure: 8.66E-08mmHg at 25°C
• Refractive Index: 1.464
• CAS DataBase Reference: METHANESULFONIC ACID 5-BOC-AMINO-PENTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: METHANESULFONIC ACID 5-BOC-AMINO-PENTYL ESTER(142342-55-0)
• EPA Substance Registry System: METHANESULFONIC ACID 5-BOC-AMINO-PENTYL ESTER(142342-55-0)

Safety Data

• Hazardous Substances Data: 142342-55-0(Hazardous Substances Data)

Usage

Uses

5-Boc-amino-pentyl Methanesulfonate can be used to treat cancer.

InChI:InChI=1/C11H23NO5S/c1-11(2,3)17-10(13)12-8-6-5-7-9-16-18(4,14)15/h5-9H2,1-4H3,(H,12,13)

Upstream product

• 75937-12-1 6-(Boc-amino)-1-hexanol 
• 124-63-0 methanesulfonyl chloride 
• 4048-33-3 6-amino-1-hexanol 
• 34619-03-9 tert-butyldicarbonate 
• 75178-90-4 N-(tert-butyloxycarbonyl)-5-aminopentanol 
• 7646-93-7 potassium hydrogensulfate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2508-29-4 5-hydroxypentylamine 

Downstream Products

• 262278-05-7 tert-butyl (5-iodo-pentyl)-carbamate 
• 1261238-07-6 tert-butyl 5-(4-amino-3-nitrophenoxy)pentylcarbamate 
• 1261238-08-7 tert-butyl 5-(3,4-diamino-phenoxy)pentylcarbamate 
• 83948-54-3 tert-butyl (5-bromopentyl)carbamate 
• 117833-90-6 (R)-2-amino-7-(Boc-amino)heptanoic acid 
• 117833-90-6 (S)-2-amino-7-(Boc-amino)heptanoic acid 
• 1610591-84-8 tert-butyl (5-(4-(2-methoxyphenyl)piperazin-1-yl)pentyl)carbamate 
• 1610591-75-7 tert-butyl (5-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)pentyl)carbamate 
• 1610591-82-6 tert-butyl (5-(4-(2,3-dichlorophenyl)piperazin-1-yl)pentyl)carbamate 
• 1610591-94-0 3-amino-N-(5-(4-(2-methoxyphenyl)piperazin-1-yl)pentyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 

Relevant articles and documents

Bioinspired Amphiphilic Peptide Dendrimers as Specific and Effective Compounds against Drug Resistant Clinical Isolates of E. coli

Evolution-derived natural compounds have been inspirational for design of numerous pharmaceuticals, e.g., penicillins and tetracyclines. Herein, we present a bioinspired strategy to design peptide dendrimers for the effective therapy of E. coli infections where the selection of appropriate amino acids and the mode of their assembly are based on the information gained from research on membranolytic natural antimicrobial peptides (AMP's). On the molecular level two opposite effects were explored: the effect of multiple positive charges necessary for membrane disintegration was equilibrated by the anchoring role of tryptophanes. Indeed, a series of Trp-terminated dendrimers exhibited high potency against clinical isolates of antibiotic resistant ESBL E. coli strains, stability in human plasma along with very low hemo- and genotoxicity. Investigation of the underlying antimicrobial mechanism indicated that the dendrimers studied at minimal inhibitory concentration showed weak permeability toward membranes. Solid-state 2D NMR studies revealed their presence on and inside the model membranes. Therefore, their biological properties might be explained by targeting of extra- or intracellular receptors. Our results point to a new approach to design novel branched antimicrobials with high therapeutic index.

Novel hydroxylamine-containing analogues of 1-guanidino-7-aminoheptane (GC7), an effective inhibitor of deoxyhypusine synthase

Earlier unknown hydroxylamine-containing analogues of 1-guanidino-7-aminohepane (GC7) containing the free aminooxy group (1-aminooxy-6-guanidinohexane), bis-guanyl derivatives of 1-aminooxy-6-aminohexane, and 1-aminooxy-5-aminopentane, and mono-guanidinoo

ACRIDIN-9-YL-AMINE, QUINOLIN-9-YL-AMINE, 1 -AMINO-9H-THIOXANTHENE-9-ONE AND BENZO[B][1,5]NAPHTHYRI DIN-10-YL-AMINE DERIVATIVES AS AUTOPHAGY INHIBITORS FOR TREATING CANCER

This disclosure provides a cridin-9-yl-amine, quinolin-9-yl-amine, 1- amino-9H-thioxanthene-9-one and benzo[b][l,5]naphthyridin-10- yl-amine derivatives and structurally related compounds for use as autophagy inhibitors for treating cancer. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 77 to 155; examples 1 to 22; compound A; compounds 1 to 21; tables 1 to 3).

Synthesis method of double different protected amino acids

The invention relates to a synthesis method of double different protected amino acids.The technical problems of harsh reaction conditions, inapplicability of production enlarging and the like in an existing synthesis method are mainly solved. According to the technical scheme, the synthesis method of double different protected amino acids comprises the following steps: one of Boc20, Alloc-Cl or Cbz-Osuis added to amino alcohol under the action of an alkaline reagent to obtain a compound 1; the compound 1 reacts with methanesulfonyl chloride or paratoluensulfonyl chloride to obtain an intermediate, then a halide is added into acetone, heating and refluxing are executed to obtain a compound 2; the compound 2 is condensed with diethyl acetamidomalonate under the action of an alkaline agent togenerate a compound 3; the compound 3 is dissolved in alcohol and water, an inorganic base is added, heating, hydrolyzing and decarboxylating are executed to obtain a compound 4; acetylase is added into deionized water to obtain a compound 5 through enzymolysis; amino acid protection is executed, wherein one of Fmoc-Osu, Cbz-OSu, Alloc-Cl or Boc20 is added into thecompound 5 under the action of an alkaline agent to generatea target compound A.

A MedChem toolbox for cereblon-directed PROTACs

A modular chemistry toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochemical properties. We equipped one terminus of the linker with a set of functional groups, e.g. protected amines, protected carboxylic acids, alkynes, chloroalkanes, and protected alcohols, all of which are considered to be attractive for PROTAC design. We also highlight different opportunities for the expansion of the medicinal chemists' PROTAC toolbox towards heterobifunctional molecules, e.g. with biotin, fluorescent, hydrophobic and peptide tags.