84-48-0Relevant articles and documents
Disproportionation of Quinone Radical Anions in Protic Solvents at High pH
Wipf, David O.,Wehmeyer, Kenneth R.,Wightman, R. Mark
, p. 4760 - 4764 (1986)
The voltammetry of anthraquinone, anthraquinone-2-sulfonate, and anthraquinone-2,6-disulfonate has been examined in aqueous and alcoholic solution with tetraethylammonium hydroxide as the supporting electrolyte.At basic values of pH, the product of the tw
Efficient and mild deamination procedure for 1-aminoanthraquinones yielding a diverse library of novel derivatives with potential biological activity
Baqi, Younis,Müller, Christa E.
supporting information, p. 6739 - 6742 (2013/01/15)
A convenient in situ method is described for reductive removal of the amino group in position 1 of the anthraquinone (AQ) moiety. The reaction proceeds smoothly within a few minutes yielding novel AQ derivatives in excellent yields. Diazonium salt formation is followed by reduction with zinc in ethanol. The method has been applied to a variety of 1-amino-AQ derivatives. It allows access to a large library of new AQ derivatives which possess potential as pharmacological tools for studying purinergic signaling, and as potential drugs, for example, for the treatment of cancer and cardiovascular diseases.
APPLICATION OF MICROWAVE ENERGY TO ORGANIC SYBNTHESIS: IMPROVED TECHNOLOGY
Abramovitch, R. A.,Abramovitch, D. A.,Iyanar, K.,Tamareselvy, K.
, p. 5251 - 5254 (2007/10/02)
The application of microwave energy to the sulfonation of naphthalene and anthraquinone, to the amination of p-chloronitrobenzene, and to the hydrosilylation of 2- and 4-vinylpyridine has been studied.Though faster (5-360-fold) reactions were observed problems were encountered with the available microwave technology.These were overcome by using a microwave oven equipped with stirring facility and both temperature and pressure control.
Potential radiosensitizing agents. 7. 4(5)-Iodo-5(4)-nitroimidazole derivatives
Gupta,Larroquette,Agrawal,Grodkowski,Neta
, p. 987 - 991 (2007/10/02)
A series of 4(5)-iodo-5(4)-nitro-1-substituted-imidazoles has been synthesized and tested for their ability to selectively radiosensitize hypoxic Chinese hamster cells (V-79) to the lethal effect of radiation. The reaction of 4(5)-iodo-5(4)-nitroimidazole with 1,2-epoxy-3-methoxypropane and ethyl α-chloroacetate produced two isomeric products in each case, which were identified by their NMR spectra. The ethyl esters were further reacted with 3-picolylamine to produce corresponding amides. The 5-iodo-4-nitroimidazole-1-N-(3-picolyl)acetamide on further reaction with m-chloroperbenzoic acid produced the corresponding N-oxide. These compounds were generally more toxic to V-79 cells than the 2-nitroimidazole derivatives and were found to be more effective radiosensitizers in vitro. The 5-iodo-4-nitroimidazole derivatives were more efficient as sensitizers than the 4-iodo-5-nitroimidazole derivatives, and the sensitizing efficiency of this class of agents was found to have significant correlation with their partition coefficients.