84-96-8 Usage
Originator
Temaril,SKF,US,1958
Uses
Trimeprazine is used for treating itching during dermatitis of both allergic and nonallergic
origin.
Manufacturing Process
95% sodamide (2.77 grams) is added to a solution of phenthiazine (9.6
grams) in xylene (140 cc) at a temperature of 130°C and the mixture is
heated with reflux for 2 hours.
A 0.61 N solution (90 cc) of 1-chloro-2-methyl-3-dimethylaminopropane in
xylene is then added over 50 minutes and heating with reflux is continued for
20 hours. After cooling, the mixture is treated with water (40 cc) and N
methanesulfonic acid (70 cc). The aqueous layer is washed with ether, treated
with aqueous sodium hydroxide (density = 1.33; 10 cc) and extracted with
ether.
The extract is dried over potassium carbonate and evaporated and the residue
is distilled in vacuo. 3-(10-phenthiazinyl)-2-methyl-1-dimethylaminopropane
(12.6 grams) is collected, distilling between 150° and 175°C under a pressure
of about 0.3 mm Hg. By dissolving this base in acetone and adding ethereal
hydrogen chloride, a hydrochloride is obtained, MP 216° to 217°C.
Check Digit Verification of cas no
The CAS Registry Mumber 84-96-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 4 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 84-96:
(4*8)+(3*4)+(2*9)+(1*6)=68
68 % 10 = 8
So 84-96-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3
84-96-8Relevant articles and documents
Isobutazine specific impurity as well as analysis method and removal method thereof
-
Paragraph 0078-0079, (2021/05/01)
The invention discloses an isobutazine specific impurity as well as an analysis method and a removal method thereof. According to the analysis method, the specific impurity Tt-2 can be effectively detected through combination of high performance liquid chromatography and an ultraviolet detector, and the impurity cannot be detected through previous EP and USP methods. According to the removal method, the specific impurity Tt-2 can be effectively removed, other process impurities can also be removed, the purity and character of the product are further improved, and the removal method has great significance in subsequent research and development of the product.
Endor Studies of Cation Radicals from Pharmacologically Active Phenothiazines
Helle, N.,Kurreck, H.,Bock, M.,Kieslich, W.
, p. 964 - 970 (2007/10/02)
A variety of substituted phenothiazine cation radicals, including those from pharmacologically active derivatives, e.g. chloropromazine, alimemazine and laevomepromazine, have been studied by means of ENDOR and TRIPLE resonace spectroscopy.These techniques allowed accurate determinations of hyperfine coupling constants, including their signs.Conclusions concerning molecular structure (e.g. twist angles) could be drawn, supporting previous investigations of the interrelationship of molecular conformations with the pharmacological potential, i.e. neuroleptic, antihistaminic or anti-Parkinsonian.