84044-04-2

Upstream product

• 65164-84-3 O,O-diphenyl {[(benzyloxy)carbonyl]amino}(phenyl)methylphosphonate 
• 100-52-7 benzaldehyde 
• 871315-40-1 C₂₆H₂₂NO₃P 
• 92-29-5 hydrobenzamide 
• 106787-27-3 diphenyl α-aminobenzylphosphonate hydrobromide 

Downstream Products

• 88081-74-7 C₃₇H₃₀NO₁₀P 
• 88024-04-8 C₃₇H₃₀NO₁₀P 
• 1448971-11-6 C₂₃H₂₂NO₆P 
• 1584736-46-8 diphenyl ((4R,5R)-4,5-diphenyl-2-thioxooxazolidin-4-yl)phosphonate 
• 1584736-70-8 diphenyl ((4R,5R)-4-phenyl-2-thioxo-5-(m-tolyl)-1-tosylimidazolidin-4-yl)phosphonate 
• 1584736-71-9 diphenyl ((4R,5R)-4-phenyl-2-thioxo-5-(o-tolyl)-1-tosylimidazolidin-4-yl)phosphonate 
• 1584736-72-0 diphenyl ((4R,5R)-5-(4-methoxyphenyl)-4-phenyl-2-thioxo-1-tosylimidazolidin-4-yl)phosphonate 
• 1584736-73-1 diphenyl ((4R,5S)-4-phenyl-5-(thiophen-2-yl)-2-thioxo-1-tosylimidazolidin-4-yl)phosphonate 
• 1584736-78-6 C₂₉H₂₄NO₅PS 
• 1584736-75-3 diphenyl ((4R,5R)-3-acetyl-2-oxo-4,5-diphenyloxazolidin-4-yl)phosphonate 
• 1584736-76-4 diphenyl ((4R,5R)-2-oxo-4,5-diphenyloxazolidin-4-yl)phosphonate 
• 1584736-74-2 C₃₃H₂₈FN₂O₆PS 
• 1584736-65-1 diphenyl ((4R,5R)-4,5-diphenyl-2-thioxo-1-tosylimidazolidin-4-yl)phosphonate 

Relevant academic research and scientific papers

A novel theranostic activity-based probe targeting kallikrein 7 for the diagnosis and treatment of skin diseases

We applied a newin silicoapproach for using protease-substrate motifs to design a kallikrein 7 (KLK7)-specific phosphonate activity-based probe (ABP) to quantify the active KLK7in situ. Epidermal application of the ABP-inhibitor onSpink5?/?Klk5

Catalytic asymmetric 1,2-addition of α-isothiocyanato phosphonates: Synthesis of chiral β-hydroxy- or β-amino-substituted α-amino phosphonic acid derivatives

α-Amino phosphonic acid derivatives are considered to be the most important structural analogues of α-amino acids and have a very wide range of applications. However, approaches for the catalytic asymmetric synthesis of such useful compounds are very limited. In this work, simple, efficient, and versatile organocatalytic asymmetric 1,2-addition reactions of α-isothiocyanato phosphonate were developed. Through these processes, derivatives of β-hydroxy-α-amino phosphonic acid and α,β-diamino phosphonic acid, as well as highly functionalized phosphonate-substituted spirooxindole, can be efficiently constructed (up to 99 % yield, d.r. >20:1, and >99 % ee). This novel method provides a new route for the enantioselective functionalization of α-phosphonic acid derivatives. Correct chirality critical: Organocatalytic asymmetric Adol-type and Mannich-type reactions of α-isothiocyanato phosphonate have been realized. Michael addition was also applicable under the same catalytic conditions. This versatile approach provides a new route for the synthesis of diverse highly optically active functionalized α-amino phosphonic acid derivatives. Copyright

Synthesis of phosphonodipeptide conjugates of ursolic acid and their homologs

To prepare novel derivatives of naturally bioactive 3β-hydroxy-urs-12- en-28-oic acid (ursolic acid) with unusual properties and broad spectrum of activities, a number of chemical reactions were conducted. First, a variety of a-aminophosphonates were prepared by a series of reactions involving the three-component Mannich type reaction as a key step. Second, an array of phosphonodipeptides and their homologs was synthesized through multistep reactions including condensation of phthalic anhydride with glycine or β-alanine, chlorination of N-blocked amino acids, coupling of acid chloride with α-aminophosphonates and sequential hydrazinolysis. Finally, new classes of phosphonodipeptide conjugates of ursolic acid and their homologs were obtained by condensation of 3β-acetoxy-urs-12-en-28-oyl chloride with phosphonodipeptides and their homologs.