84138-78-3

Upstream product

• 59-50-7 4-Chloro-3-methylphenol 
• 72293-68-6 2-(4-chloro-3-methylphenoxy)acetohydrazide 
• 588-20-5 4-chloro-3-methylphenoxyacetic acid 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 123282-38-2 5-(4-Chloro-3-methylphenoxymethyl)-2-(furylidenimino)-1,3,4-thiadiazole 
• 119869-08-8 [5-(4-Chloro-3-methyl-phenoxymethyl)-[1,3,4]thiadiazol-2-yl]-[1-phenyl-meth-(Z)-ylidene]-amine 
• 1263183-80-7 C₁₄H₁₂ClN₃O₂S 
• 1253415-26-7 C₁₇H₁₃ClN₄OS₂ 
• 1253415-04-1 C₁₉H₁₉ClN₄O₂S₂ 
• 1253415-02-9 C₁₈H₁₇ClN₄O₂S₂ 
• 1253415-29-0 C₁₈H₁₅ClN₄O₂S₂ 
• 1253415-01-8 C₁₈H₁₇ClN₄OS₂ 
• 1253415-27-8 C₁₈H₁₅ClN₄OS₂ 
• 1253415-00-7 C₁₇H₁₅ClN₄OS₂ 
• 123282-45-1 2-(4-Chloro-3-methylphenoxymethyl)-7-furano-6-phenyl-1,3,4-thiadiazolo<3,2-a>-s-triazine-5-thione 
• 123282-58-6 2-(4-Chloro-3-methylphenoxymethyl)-1,3,4-thiazolo-<5,1-b>imidazol-6-one 
• 123282-51-9 2-(Chloroacetamido)-5-(4-chloro-3-methylphenoxymethyl)-1,3,4-thiadiazole 
• 119869-09-9 [5-(4-Chloro-3-methyl-phenoxymethyl)-[1,3,4]thiadiazol-2-yl]-[1-(4-chloro-phenyl)-meth-(Z)-ylidene]-amine 

Relevant academic research and scientific papers

Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2- (phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives

An elevated level of blood uric acid (hyperuricemia) is the underlying cause of gout. Xanthine oxidase is the key enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid. Allopurinol, a widely used xanthine oxidase inhibitor is the most commonly used drug to treat gout. However, a small but significant portion of the population suffers from adverse effects of allopurinol that includes gastrointestinal upset, skin rashes and hypersensitivity reactions. Moreover, an elevated level of uric acid is considered as an independent risk factor for cardiovascular diseases. Therefore use of allopurinol-like drugs with minimum side effects is the ideal drug of choice against gout. In this study, we report the synthesis of a series of pyrimidin-5-one analogues as effective and a new class of xanthine oxidase inhibitors. All the synthesized pyrimidin-5-one analogues are characterized by spectroscopic techniques and elemental analysis. Four (6a, 6b, 6d and 6f) out of 20 synthesized molecules in this class showed good inhibition against three different sources of xanthine oxidase, which were more potent than allopurinol based on their respective IC50 values. Molecular modeling and docking studies revealed that the molecule 6a has very good interactions with the Molybdenum-Oxygen-Sulfur (MOS) complex a key component in xanthine oxidase. These results highlight the identification of a new class of xanthine oxidase inhibitors that have potential to be more efficacious, than allopurinol, to treat gout and possibly against cardiovascular diseases.

Synthesis and biological evaluation of some novel 2-mercaptobenzothiazoles carrying 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole moieties

Several 2-mercaptobenzothiazole derivatives containing 1,3,4-oxadiazoles, 1,2,4-triazoles and 1,3,4-thiadiazoles at the second position were synthesized. Some of these synthesized compounds were evaluated for their in vivo analgesic, anti-inflammatory, acute toxicity and ulcerogenic actions. Some of the tested compounds showed significant analgesic and anti-inflammatory activities. Two of the compounds showed significant gastrointestinal protection compared to the standard drug diclofenac sodium. The compounds were also tested for their in vitro antimicrobial activity with most displaying selective activity against the Gram-negative bacteria Pseudomonas aeruginosa. In the present investigation the tested compounds did not possess antifungal activity.