72293-68-6

Usage

Uses

Used in Pharmaceutical Industry:
(4-CHLORO-3-METHYL-PHENOXY)-ACETIC ACID HYDRAZIDE is used as a starting material for the synthesis of various pharmaceuticals. Its hydrazide group allows for the creation of hydrazide-based derivatives with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (4-CHLORO-3-METHYL-PHENOXY)-ACETIC ACID HYDRAZIDE is utilized as a precursor in the production of agrochemicals. Its reactivity with other organic compounds enables the development of new products with agricultural applications.
Used in Organic Synthesis:
(4-CHLORO-3-METHYL-PHENOXY)-ACETIC ACID HYDRAZIDE is used as a reagent or intermediate in organic synthesis. Its ability to react with other organic compounds contributes to the formation of new products with diverse chemical and biological properties, expanding its utility in various chemical reactions and processes.

InChI:InChI=1/C9H11ClN2O2/c1-6-4-7(2-3-8(6)10)14-5-9(13)12-11/h2-4H,5,11H2,1H3,(H,12,13)

Upstream product

• 59-50-7 4-Chloro-3-methylphenol 
• 30406-61-2 ethyl 2-(4-chloro-3-methylphenoxy)acetate 
• 117554-55-9 Methyl 4-chloro-3-methylphenoxyacetate 

Downstream Products

• 84396-79-2 C₁₈H₂₀ClN₃O₂S 
• 84160-90-7 2-(4-Chloro-3-methyl-phenoxy)-N-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide 
• 78613-20-4 2-Amino-5-(4'-chloro-3'-methylphenoxymethyl)-1,3,4-oxadiazole 
• 125299-02-7 (4-Chloro-3-methyl-phenoxy)-acetic acid [2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide 
• 84396-80-5 C₁₆H₁₄Cl₃N₃O₂S 
• 84396-78-1 C₁₇H₁₈ClN₃O₃S 
• 120353-50-6 5-(4-chloro-3-methylphenoxy)methyl-3-(2,4-dichlorophenyl)aminomethyl-1,3,4-oxadiazole-2-thione 
• 72385-02-5 5-(4-chloro-3-methylphenoxy)methyl-3-(4-chlorophenyl)aminomethyl-1,3,4-oxadiazole-2-thione 
• 120353-49-3 5-(4-chloro-3-methylphenoxy)methyl-3-(2-chlorophenyl)aminomethyl-1,3,4-oxadiazole-2-thione 
• 120353-51-7 5-(4-chloro-3-methylphenoxy)methyl-3-(2-ethoxyphenyl)aminomethyl-1,3,4-oxadiazole-2-thione 
• 72384-92-0 2-(3'-methyl-4'-chlorophenoxymethyl)-Δ²-1,3,4-oxadiazoline-5-thione 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel aryloxyacetic acid hydrazide derivatives as anticancer agents

In our continuing search for new anticancer agents, herein we report the synthesis of 2-(4-chloro-3-methylphenoxy)-N'-[(aryl)methylidene]acetohydrazides 3a–j and the evaluation of their anticancer activities on cell viability, morphological changes and ca

Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2- (phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives

An elevated level of blood uric acid (hyperuricemia) is the underlying cause of gout. Xanthine oxidase is the key enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid. Allopurinol, a widely used xanthine oxidase inhibitor is the most commonly used drug to treat gout. However, a small but significant portion of the population suffers from adverse effects of allopurinol that includes gastrointestinal upset, skin rashes and hypersensitivity reactions. Moreover, an elevated level of uric acid is considered as an independent risk factor for cardiovascular diseases. Therefore use of allopurinol-like drugs with minimum side effects is the ideal drug of choice against gout. In this study, we report the synthesis of a series of pyrimidin-5-one analogues as effective and a new class of xanthine oxidase inhibitors. All the synthesized pyrimidin-5-one analogues are characterized by spectroscopic techniques and elemental analysis. Four (6a, 6b, 6d and 6f) out of 20 synthesized molecules in this class showed good inhibition against three different sources of xanthine oxidase, which were more potent than allopurinol based on their respective IC50 values. Molecular modeling and docking studies revealed that the molecule 6a has very good interactions with the Molybdenum-Oxygen-Sulfur (MOS) complex a key component in xanthine oxidase. These results highlight the identification of a new class of xanthine oxidase inhibitors that have potential to be more efficacious, than allopurinol, to treat gout and possibly against cardiovascular diseases.

Synthesis, characterization and antimicrobial evaluation of novel imines and thiazolidinones

2-(4-Chloro-3-methylphenoxy)acetohydrazide (2) derived from ethyl 2-(4-chloro-3-methylphenoxy) acetate (1) was reacted with different aromatic aldehydes to yield N-(substituted benzylidiene)-2-(4-chloro-3- methylphenoxy)acetamide (3a-e). Cyclization of compound (3a-e) with thioglycolic acid yielded 2-(4-chloro- 3-methylphenoxy)-N-(4-oxo-2-arylthiazolidin-3-yl) acetamide (4a-e). The newly synthesized compounds were characterized on the basis of spectral studies and evaluated for antibacterial and antifungal activities.

Synthesis, Characterization, Spectral and Antifungal Properties of Some 5-Substituted-1,3,4-oxadiazole-2-thiones and Their Mannich Bases

A series of 5-substituted aryloxymethyl-1,3,4-oxadiazole-2-thione (3a-e) and their Mannich bases 4-8 are synthesized and subjected to fungitoxic screening.The structures of these compounds are established on the basis of elemental analysis 1H-n.m.r. and mass spectral data.The mass spectral fragmentation pathways of these compounds are discussed.

Synthesis and Biological Activity of 3-Pentadecylaryloxyacetic Acids, Their Hydrazides and Cyclic Derivatives: Oxadiazoles and Pyrroles

Several 3-pentadecylaryloxyacetic acids (III), their hydrazides (IV), 2-amino-5-(3'-pentadecylaryloxymethyl)-1,3,4-oxadiazoles (V) and 1-(3'-pentadecylaryloxyacetamido)-2,5-dimethylpyrroles (VI) have been synthesised and evaluated for their biological activity.Some of the compounds exhibit strong antiinflammatory action in experimental animals.Presence of a long alkyl chain (C13H31) renders the compounds to be less toxic.