84151-71-3

Basic information

• Product Name: dichlorobis(2-methyl-5-nitro-1H-imidazole-1-ethanol-N3)platinum
• Synonyms: dichlorobis(2-methyl-5-nitro-1H-imidazole-1-ethanol-N3)platinum;dichlorobis(1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole)platinum (II)
• CAS NO: 84151-71-3
• Molecular Formula: C₁₂H₁₈Cl₂N₆O₆Pt
• Molecular Weight: 607.28398
• EINECS: 282-317-6
• Mol File: 84151-71-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 405.4°C at 760 mmHg
• Flash Point: 199°C
• Appearance: /
• Vapor Pressure: 2.67E-07mmHg at 25°C
• CAS DataBase Reference: dichlorobis(2-methyl-5-nitro-1H-imidazole-1-ethanol-N3)platinum(CAS DataBase Reference)
• NIST Chemistry Reference: dichlorobis(2-methyl-5-nitro-1H-imidazole-1-ethanol-N3)platinum(84151-71-3)
• EPA Substance Registry System: dichlorobis(2-methyl-5-nitro-1H-imidazole-1-ethanol-N3)platinum(84151-71-3)

Safety Data

• Hazardous Substances Data: 84151-71-3(Hazardous Substances Data)

Usage

InChI:InChI=1/2C6H9N3O3.2ClH.Pt/c2*1-5-7-4-6(9(11)12)8(5)2-3-10;;;/h2*4,10H,2-3H2,1H3;2*1H;/q;;;;+2/p-2

Upstream product

• 85027-01-6 Pt(metronidazole)2I₂ 
• 10025-99-7 potassium tetrachloroplatinate(II) 
• 443-48-1 metronidazole 
• 84151-71-3 cis-Pt(metronidazole)2Cl₂ 

Downstream Products

• 84151-71-3 [SP-4-1]-dichlorobis(2-methyl-5-nitro-1H-imidazole-1-ethanol-κN(3))platinum(II) 

Relevant articles and documents

The preparation and isomerization of platinum metronidazole complexes: X-ray crystal and molecular structures of cis- and trans-dichlorobis[1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole]-platinum(II)

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Synthesis, crystal structure, and enhancement of the efficacy of metronidazole against Entamoeba histolytica by complexation with palladium(II), platinum(II), or copper(II)

Reaction of trans-[PdCl2(DMSO)2], cis-[PtCl2(DMSO)2], and [Cu(OAc)2]·H2O with metronidazole (mnz) leads to the formation of new complexes, i.e., trans-[PdCl2(mnz)2] (1), trans-[PtCl2(mnz)2], (2), and trans-[Cu2(OAc)4(mnz)2] (3), respectively. Complexes 1-3 crystallize all in the centrosymmetric monoclinic space group P21/c with Z=8. Unit-cell parameters for these complexes are: 1, a=7.1328(14) A, b=20.699(4) A, c= 7.1455(14) A, and β=116.17(3)°; 2, a=6.9169(14) A, b=21.853(4) A, c=6.7218(13) A, and β=110.79(3)°; 3, a=9.1663(18) A, b=19.129(4) A, c=8.9446(18) A, and β=116.44(3)°. The complexes 1 and 2 maintain an ideal square-planar geometry. In complex 3, the H2O molecules of the starting complex are replaced by metronidazole while maintaining a dimeric structure of [Cu(OAc)2]. Each Cu ion has an ideal octahedral structure, though distortion occurs in the equatorial position where the acetato ligands are attached. The Cu-Cu separation of 2.6343(8) A indicates considerable metal-metal interaction. The testing of the antiamoebic activity of these complexes against the protozoan parasite Entamoeba histolytica suggests that compound 1-3 might be endowed with important antiamoebic properties since they showed IC50 values in a μM range better than metronidazole (Table 2). Thus, compound 1 displayed more effective amoebicidal activity than metronidazole (IC50 values of 0.103 μM vs. 1.50 μM, resp.).