84151-71-3Relevant academic research and scientific papers
Synthesis, crystal structure, and enhancement of the efficacy of metronidazole against Entamoeba histolytica by complexation with palladium(II), platinum(II), or copper(II)
Bharti, Neelam,Shailendra,Coles, Simon J.,Hursthouse, Michael B.,Mayer, Thomas A.,Gonzalez Garza,Cruz-Vega, Delia E.,Mata-Cardenas, Benito D.,Naqvi, Fehmida,Maurya, Mannar R.,Azam, Amir
, p. 2704 - 2712 (2007/10/03)
Reaction of trans-[PdCl2(DMSO)2], cis-[PtCl2(DMSO)2], and [Cu(OAc)2]·H2O with metronidazole (mnz) leads to the formation of new complexes, i.e., trans-[PdCl2(mnz)2] (1), trans-[PtCl2(mnz)2], (2), and trans-[Cu2(OAc)4(mnz)2] (3), respectively. Complexes 1-3 crystallize all in the centrosymmetric monoclinic space group P21/c with Z=8. Unit-cell parameters for these complexes are: 1, a=7.1328(14) A, b=20.699(4) A, c= 7.1455(14) A, and β=116.17(3)°; 2, a=6.9169(14) A, b=21.853(4) A, c=6.7218(13) A, and β=110.79(3)°; 3, a=9.1663(18) A, b=19.129(4) A, c=8.9446(18) A, and β=116.44(3)°. The complexes 1 and 2 maintain an ideal square-planar geometry. In complex 3, the H2O molecules of the starting complex are replaced by metronidazole while maintaining a dimeric structure of [Cu(OAc)2]. Each Cu ion has an ideal octahedral structure, though distortion occurs in the equatorial position where the acetato ligands are attached. The Cu-Cu separation of 2.6343(8) A indicates considerable metal-metal interaction. The testing of the antiamoebic activity of these complexes against the protozoan parasite Entamoeba histolytica suggests that compound 1-3 might be endowed with important antiamoebic properties since they showed IC50 values in a μM range better than metronidazole (Table 2). Thus, compound 1 displayed more effective amoebicidal activity than metronidazole (IC50 values of 0.103 μM vs. 1.50 μM, resp.).
Platinum(II) Complexes of Nitroimidazoles: Synthesis, Characterisation, and X-Ray Crystal Structures of cis-dichlorobisplatinum(II) and trans-dichlorobisplatinum(II)
Bales, John R.,Mazid, Muhammed A.,Sadler, Peter J.,Aggarwal, Aneel,Kuroda, Reiko,et al.
, p. 795 - 802 (2007/10/02)
A range of complexes of type 2X2> (where L is a substituted 5-nitroimidazole, and X2 is a dihalide or a dicarboxylate) has been prepared and characterised by a variety of methods, including 195Pt n.m.r. spectroscopy.These 5-nitroimidazole complexes had a cis stereochemistry as exemplified by the X-ray crystal-structure determination of cis-dichlorobisplatinum(II) .In addition, a number of analogous complexes of 2- and 4-nitroimidazoles were prepared.The 2-nitroimidazoles appeared to form the thermodynamically favoured trans complexes, rather than the kinetically favoured cis products.This was verified for trans-dichlorobisplatinum(II) 1/a>.This complex showed an unusual loss of planarity between the nitro-group and the imidazole ring, giving a dihedral angle of 45.6 deg.The geometry of the 4-nitroimidazole complexes was not determined.Co-ordination of the nitroimidazole ligand to PtII lowered the wavelength of the ?-?* electronic absorption band, and reduced the polarographic reduction potential by ca. 0.15-0.2V.
