84156-18-3

Upstream product

• 103205-37-4 (Z)-2-Amino-3-(4-methoxy-phenyl)-acrylic acid 
• 6630-33-7 ortho-bromobenzaldehyde 
• 81568-83-4 N-(2-bromobenzoyl)glycine 
• 123-11-5 4-methoxy-benzaldehyde 
• 7154-66-7 2-bromobenzoic acid chloride 
• 207864-20-8 ethyl N-(o-bromobenzoyl)aminoacetate 

Downstream Products

• 84156-23-0 2-(2-Bromo-phenyl)-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3-(4-phenylamino-phenyl)-3,5-dihydro-imidazol-4-one 
• 84158-35-0 N-(4-{2-(2-Bromo-phenyl)-4-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-5-oxo-4,5-dihydro-imidazol-1-yl}-phenyl)-2-chloro-N-phenyl-acetamide 
• 84158-30-5 N-(4-{2-(2-Bromo-phenyl)-4-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-5-oxo-4,5-dihydro-imidazol-1-yl}-phenyl)-N-phenyl-acetamide 
• 84156-27-4 2-(2-Bromo-phenyl)-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3-(10H-phenothiazin-3-yl)-3,5-dihydro-imidazol-4-one 

Relevant academic research and scientific papers

Substituents effect on the erlenmeyer-ploechl reaction: Understanding an observed process reaction time

A systematic study on hippuric acid substituents was performed in order to better understand the influence of stereoelectronic factors on the Erlenmeyer reaction rate. In addition, two reaction systems were evaluated: Huenig's base solvent free conditions and catalytic sodium acetate in 2-methyl-THF. The effect on reaction rate of electron withdrawing and electron donating groups are reported. Specifically, the study led to the conclusion that stereoelectronic factors have significant influence in one of our key Erlenmeyer reaction by affecting its reaction rate.

Imidazolines Containing Biologically Active Units: Part I- Synthesis of Imidazolines Containing Various Biologically Active Units

2-Aryl-4-arylidene-Δ2-oxazoline-5-ones (I) react with p-aminodiphenylamine to give 2-aryl-4-arylidene-1-(p-phenylaminophenyl)-Δ2-imidazolin-5-ones (II) which undergo cyclization with sulphur to the corresponding phenothiazine derivat