84199-57-5

Basic information

• Product Name: 1-(2-bromopyridin-3-yl)ethanol
• Synonyms: 1-(2-bromopyridin-3-yl)ethanol;3-Pyridinemethanol, 2-bromo-.alpha.-methyl-;1-(5-Bromo-3-methyl-pyridin-2-yl)-ethanol
• CAS NO: 84199-57-5
• Molecular Formula: C₇H₈BrNO
• Molecular Weight: 202.04852
• Mol File: 84199-57-5.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-bromopyridin-3-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromopyridin-3-yl)ethanol(84199-57-5)
• EPA Substance Registry System: 1-(2-bromopyridin-3-yl)ethanol(84199-57-5)

Safety Data

• Hazardous Substances Data: 84199-57-5(Hazardous Substances Data)

Usage

General Description

1-(2-bromopyridin-3-yl)ethanol, also known as 2-Bromopyridin-3-yl)ethanol, is a chemical compound with the molecular formula C7H8BrNO. It is a colorless to pale yellow liquid with a molecular weight of 206.04 g/mol. 1-(2-bromopyridin-3-yl)ethanol is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has the potential to function as a building block in the synthesis of various biologically active compounds. Due to its versatile nature, 1-(2-bromopyridin-3-yl)ethanol is a valuable chemical in the field of organic chemistry and drug discovery. However, it is important to handle this compound with caution, as it is a potentially hazardous material and should be used in a controlled laboratory setting with appropriate safety measures in place.

Upstream product

• 109-04-6 2-bromo-pyridine 
• 75-07-0 acetaldehyde 
• 128071-75-0 2-bromopyridine-3-carboxaldehyde 
• 676-58-4 methylmagnesium chloride 
• 84199-61-1 1-(2′-bromo-3′-pyridyl)ethan-1-one 
• 75-16-1 methylmagnesium bromide 
• 626-05-1 2,6-Dibromopyridine 

Downstream Products

• 58531-32-1 3-ethylpiperidine hydrochloride 
• 1350845-41-8 1-(5-methyl-1,6-naphthyridin-7-yl)cyclohexanol 
• 1350845-24-7 7-(4-methoxyphenyl)-5-methyl-1,6-naphthyridine 
• 1350845-19-0 5-methyl-7-p-tolyl-1,6-naphthyridine 
• 1350844-61-9 1-(2-((1-hydroxycyclohexyl)ethynyl)pyridin-3-yl)ethanone 
• 1350844-43-7 1-(2-((3-(trifluoromethyl)phenyl)ethynyl)pyridin-3-yl)ethanone 
• 1350844-38-0 1-(2-((4-methoxyphenyl)ethynyl)pyridin-3-yl)ethanone 
• 1284294-04-7 1-(2-(p-tolylethynyl)pyridin-3-yl)ethanone 
• 1020104-87-3 N-[1-(2-methoxy-pyridin-3-yl)-ethyl]-N-(4-p-tolyloxy-phenyl)-methane-sulfonamide 
• 84199-61-1 1-(2′-bromo-3′-pyridyl)ethan-1-one 

Relevant articles and documents

Phosphine- and water-promoted pentannulative aldol reaction

Herein, an efficient metal-free intramolecular aldol reaction for the synthesis of an unusual class of cyclopentanoids is described. The reaction of α-substituted dienones tethered with ketones in the presence of tributylphosphine and water provided aldols. The role of water was realised to be crucial for this transformation. Furthermore, isotopic labeling experiments provided vital information about the reaction mechanism.

One-Pot Asymmetric Synthesis of Alkylidene 1-Alkylindan-1-ols Using Br?nsted Acid and Palladium Catalysis

A one-pot catalytic enantioselective allylboration/Mizoroki-Heck reaction of 2-bromoaryl ketones has been developed for the asymmetric synthesis of 3-methyleneindanes bearing a tertiary alcohol center. Br?nsted acid-catalyzed allylboration with a chiral BINOL derivative was followed by a palladium-catalyzed Mizoroki-Heck cyclization, resulting in selective formation of the exo-alkene. This novel protocol provides a concise and scalable approach to 1-alkyl-3-methyleneindan-1-ols in high enantiomeric ratios (up to 96:4 er). The potential of these compounds as chiral building blocks was demonstrated with efficient transformation to optically active diol and amino alcohol scaffolds.

Silver-catalysed intramolecular cyclisation of 2-alkynylacetophenones and 3-acetyl-2-alkynylpyridines in the presence of ammonia

Silver-catalysed/microwave-assisted domino reactions of 2-alkynyl-acetophenones and 3-acetyl-2-alkynylpyridines in the presence of ammonia are widely described. In most cases the reaction give a mixture of the imino- and carbo-cyclisation products, with a