842-58-0Relevant articles and documents
Melamine-Based Porous Organic Polymers Supported Pd(II)-Catalyzed Addition of Arylboronic Acids to Aromatic Aldehydes
Shen, Kai,Wen, Min,Fan, Chaogang,Lin, Shaohui,Pan, Qinmin
, p. 2612 - 2621 (2021/01/15)
Abstract: A new type melamine-based porous organic polymers (SZU-1) has been synthesized with melamine and 2,2′-bipyridyl-5,5′-dialdehyde by a one-pot method and fully characterized. Divalent palladium salts were coordinated to this polymer network which successfully catalyzed the nucleophilic addition reaction of arylboronic acids to aromatic aldehydes. With only 1.0?mol% heterogeneous catalyst loading, high reaction yields (>?85%) can be achieved in most cases. The scope of substrates was also investigated and the catalyst showed universal applicability. Graphic Abstract: The loose and porous melamine-based porous organic polymers (SZU-1) are synthesized by melamine and 2,2′-bipyridyl-5,5′-dialdehyde. The performance of SZU-1 was characterized and most of the substrates achieved high yield (> 85%) in the catalytic performance test.[Figure not available: see fulltext.]
An Efficient Ga(OTf)3/Isopropanol Catalytic System for Direct Reduction of Benzylic Alcohols
Sai, Masahiro
supporting information, p. 4330 - 4335 (2018/10/15)
This study aims to report the first gallium-catalyzed direct reduction of benzylic alcohols using isopropanol as a reductant. The reaction proceeds via gallium catalyst-assisted hydride transfer of the in situ-generated benzylic isopropyl ether. The method generates only water and acetone as byproducts and thus provides an atom-economic and environmentally friendly approach to the synthesis of di- and triarylmethanes, which are important substructures in various bioactive compounds and functional materials. (Figure presented.).
The cooperative effect of Lewis pairs in the Friedel-Crafts hydroxyalkylation reaction: A simple and effective route for the synthesis of (±)-carbinoxamine
Harikrishnan, Adhikesavan,Sanjeevi, Jayakumar,Ramanathan, Chinnasamy Ramaraj
, p. 3633 - 3647 (2015/03/30)
An efficient C-C bond formation strategy between aromatic/heteroaromatic π-nucleophiles and Lewis acid activated aldehydes is described. This aromatic electrophilic substitution reaction of arenes or heteroarenes is facilitated by Lewis acid AlBr3. Aromatic rings with electron donating substituents are excellent nucleophilic counterparts in this reaction, generating carbinols in excellent yields (61-94%). The formation of triarylmethanes is also witnessed in the case of certain reactive aldehydes and aromatic π-nucleophiles through reactive carbocation formation. The formation of triarylmethane is reduced to a greater extent via retardation of the second π-nucleophile addition through a Lewis base, for example, pyridine, coordination with an aluminium alkoxide intermediate. Various aliphatic aldehydes also underwent Friedel-Crafts type hydroxyalkylation and generated the expected carbinols in moderate yields (41-53%) in the presence of AlBr3. This protocol has been successfully applied to the synthesize of the (±)-carbinoxamine, a therapeutically important histamine H1 antagonist, in a one-pot manner.
