84200-06-6

Basic information

• Product Name: 4-Pyridinepropanenitrile
• Synonyms: 3-PYRIDIN-4-YLPROPANENITRILE;3-PYRIDIN-4-YL-PROPIONITRILE;4-PYRIDINEPROPANENITRILE;3-(Pyridine-4-yl)propanenitrile
• CAS NO: 84200-06-6
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.16
• Mol File: 84200-06-6.mol

Chemical Properties

• Boiling Point: 302 °C
• Flash Point: 110 °C
• Appearance: /
• Density: 1.054
• Vapor Pressure: 0.000988mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Pyridinepropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinepropanenitrile(84200-06-6)
• EPA Substance Registry System: 4-Pyridinepropanenitrile(84200-06-6)

Safety Data

• Hazardous Substances Data: 84200-06-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Pyridinepropanenitrile is used as a chemical intermediate for the synthesis of pharmaceutical compounds. Its nitrile group plays a crucial role in the formation of various drug molecules, contributing to their therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Pyridinepropanenitrile is utilized as a precursor in the production of agrochemicals. Its functional group aids in the development of compounds that can be used in pesticides or other agricultural applications, enhancing crop protection and yield.
Used in Dye Industry:
4-Pyridinepropanenitrile is employed as a building block in the synthesis of dyes. The nitrile group in the compound contributes to the color and stability of the dyes, making it an essential component in the production of various types of colorants for different industries.
It is important to handle 4-Pyridinepropanenitrile with caution due to its harmful effects if ingested or if it comes into contact with the skin. Proper safety measures should be taken to minimize the risk of exposure.

InChI:InChI=1/C8H8N2/c9-5-1-2-8-3-6-10-7-4-8/h3-4,6-7H,1-2H2

Upstream product

• 24490-79-7 3-pyridin-4-yl-acrylonitrile 
• 100-48-1 pyridine-4-carbonitrile 
• 107-13-1 acrylonitrile 
• 872-85-5 pyridine-4-carbaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 1121-60-4 pyridine-2-carbaldehyde 
• 84200-07-7 3-(pyridin-4-yl)-propionamide 
• 5344-27-4 4-(2-hydroxyethyl)pyridine 
• 28148-48-3 2-(pyridin-4-yl)ethyl chloride 
• 151-50-8 potassium cyanide 
• 100-43-6 4-vinylpyridine 
• 74-90-8 hydrogen cyanide 

Downstream Products

• 6318-43-0 3-pyridin-4-yl-propionic acid 
• 501379-51-7 3-(1-oxide-4-pyridyl)propionitrile 
• 52809-19-5 ethyl 4-pyridinepropanoate 

Relevant articles and documents

Electroreductive 4-Pyridylation of Electron-deficient Alkenes with Assistance of Ni(acac)2

An electroreductive 4-pyridylation of activated alkenes was developed in an undivided cell with the assistance of Ni(acac)2 (acac = acetylacetone). This novel protocol is compatible with a broad range of electron-poor alkenes, which are commonl

Synthesis of Nitriles from Aldehydes with Elongation of the Molecule with Two Carbon Atoms

A new protocol for the synthesis of nitriles from carbonyl compounds with elongation of the molecule with two carbon atoms was developed. It involves a reaction of ethyl cyanoacetate with different aldehydes in the presence of iron pentacarbonyl as a redu

1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF

This invention provides a compound represented by the formula (I) :wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents;R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents;n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I) , which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

Nα-Imidazolylalkyl and Pyridylalkyl Derivatives of Histaprodifen: Synthesis and in Vitro Evaluation of Highly Potent Histamine H1-Receptor Agonists

A novel series of Nα-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen (6, 2-[2-(3,3-diphenylpropyl)imidazol-4-yl]ethanamine) was synthesized and evaluated as histamine H1-receptor agonists. The title compounds displayed partial agonism at contractile H1-receptors of guinea pig ileum and were at least equipotent with histamine. Agonist effects of the new derivatives were susceptible to blockade by the H1-receptor antagonist mepyramine (2-100 nM). In the imidazole series, suprahistaprodifen (51, [2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethyl]-[2-(1H-imidazol-4-yl) ethyl]amine, Nα-2-[(1H-imidazol-4-yl)ethyl]histaprodifen) showed the highest H1-receptor agonist potency ever reported in the literature (pEC50 8.26, efficacy Emax 96%). Elongation of the alkyl spacer from ethyl to butyl decreased activity from 3630% (ethyl, 51) to 163% (butyl, 53) of histamine potency. The exchange of the terminal imidazole nucleus for a pyridine ring resulted in compounds with comparably high potency. A decrease in agonist potency and efficacy was observed when the attachment of the alkyl spacer was consecutively changed from the ortho to the meta and the para position, respectively, of the pyridine ring. The pyridine series that contained a butyl chain possessed the highest potency and affinity. Nα-[4-(2-pyridyl)butyl]histaprodifen (56) emerged as a strong partial agonist, being almost equipotent with 51 (pEC50 8.16, E max 89%). Compounds 51 and 56 also showed potent partial agonism at contractile H1 receptors in guinea pig aorta and potently activated H1-receptor-mediated endothelium-dependent relaxation in the rat aorta. Compounds 51-65 displayed low to moderate affinity at H2, H3, and M3 receptors in functional models of guinea pig. Collectively, Nα-imidazolylalkyl- and Nα -pyridylalkyl-substituted histaprodifens represent a novel class of potent H1-receptor agonists. These compounds may be useful to define the (patho)physiological role of the H1-receptor and refine molecular models of H1-receptor activation.

Penicillanic acid derivatives

6-Amidinopenicillanic acid derivatives wherein one of the nitrogen atoms of the amidino group is part of a heterocyclic ring having on a side chain an unsubstituted heterocyclic ring containing 2 to 3 nitrogen atoms, and being useful as an antibiotic.