84280-95-5Relevant articles and documents
Synthesis, Antioxidant Activity and Cytotoxicity of N-Functionalized Organotellurides
Bandeira, Pamela T.,Dalmolin, Mara C.,de Oliveira, Mariana M.,Nunes, Karine C.,Garcia, Francielle P.,Nakamura, Celso V.,de Oliveira, Alfredo R.M.,Piovan, Leandro
, p. 410 - 415 (2019)
The use of antioxidants is the most effective means to protect the organism against cellular damage caused by oxidative stress. In this context, organotellurides have been described as promising antioxidant agents for decades. Herein, a series of N-functionalized organotellurium compounds has been tested as antioxidant and presented remarkable activities by three different in vitro chemical assays. They were able to reduce DPPH[rad] radical with IC50 values ranging from 5.08 to 19.20 μg mL?1, and some of them also reduced ABTS[rad]+ radical and TPTZ-Fe3+ complex in ABTS[rad]+ and FRAP assays, respectively. Initial structure-activity relationship discloses that the nature of N-substituent strongly influenced both activity and cytotoxicity of the studied compounds. Furthermore, radical scavenging activities of N-functionalized organotellurides have been compared with those of their selenilated congeners, demonstrating that the presence of tellurium atom has an essential role in antioxidant activity.
Stereoselective Bioreduction of Telluro-Acetophenones to Optically Active Hydroxy Tellurides
Bandeira, Pamela Taisline,Gotor-Fernández, Vicente,Piovan, Leandro
, (2020/02/27)
Organotellurium compounds exhibit a broad range of useful applications in organic synthesis, materials science and medicinal chemistry fields. Despite their increasing applicability, the synthesis of enantiomerically pure organotellurium compounds remains nowadays scarcely reported in the literature. Herein, the chemical synthesis and biocatalyzed reductions of a set of telluro-acetophenones using both (R) and (S)-selective alcohol dehydrogenases (ADHs) is described for the first time, obtaining enantiomerically enriched hydroxy tellurides with excellent selectivities under very mild reaction conditions. On the one hand, enantiopure para-substituted (S)-hydroxy tellurides were obtained using the Ras-ADH (77–95 % conversion) and ADH-A (52–75 %), the ADH-A leading to the enantiopure (S)-hydroxy tellurides substituted at the meta-position (69–75 %). On the other hand, the evo-1.1.200 displayed high selectivity towards the preparation of optically alcohols with substitutions at the para-position of the aromatic ring (60–68 % conversion and 92–97 % ee), while the Lb-ADH led to the best results when reducing bulky ketones at the meta-position (79–82% conversion and 88–99 % ee).
Pentafluoro(aryl)-λ6-tellanes and Tetrafluoro(aryl)(trifluoromethyl)-λ6-tellanes: From SF5 to the TeF5 and TeF4CF3 Groups
Bornemann, Dustin,Pitts, Cody Ross,Ziegler, Carmen J.,Pietrasiak, Ewa,Trapp, Nils,Kueng, Sebastian,Santschi, Nico,Togni, Antonio
supporting information, p. 12604 - 12608 (2019/08/16)
The TeF5 group is significantly underexplored as a highly fluorinated substituent on an organic framework, despite it being a larger congener of the acclaimed SF5 group. In fact, only one aryl-TeF5 compound (phenyl-TeFsub
