84324-12-9

Usage

Chemical Properties

White Solid

Uses

An intermediate in the synthesis of Ramipril.

Upstream product

• 134206-11-4 (1'S,2R)-2-(1'-Methyl-2'-oxo-2'-phenylmethoxy-ethylamino)-4-oxo-4-phenyl-buttersaeure-ethylester 
• 93836-43-2 (R)-benzyl α-trifluoromethanesulphonyloxy propanoate 
• 124044-66-2 (R)-ethyl 2-amino-4-phenylbutanoate 
• 104-53-0 3-phenyl-propionaldehyde 
• 90365-91-6 (-)-α-[(Trifluoromethyl)sulfonyl]oxy-4-phenylbutyric acid,ethyl ester 
• 93921-85-8 ethyl 2-hydroxy-4-phenylbutanoate 
• 15121-89-8 ethyl (E)-4-oxo-4-phenyl-2-butenoate 
• 121842-75-9 N-carbamyl (R)-2-amino-4-phenylbutyric acid 
• 121842-77-1 (R)-ethyl 2-bromo-4-phenylbutyrate 
• 121842-76-0 (R)-2-bromo-4-phenylbutyric acid 
• 120379-81-9 5-phenylethyl-imidazolidine-2,4-dione 
• 80828-28-0 N-<(R)-1-(ethoxycarbonyl)-3-phenylpropyl>-L-alanine tert-butylester 
• 93841-86-2 N-<1(R)-(Ethoxycarbonyl)-3-phenylpropyl>-(S)-alanin-benzylester 

Downstream Products

• 90891-24-0 (R)-2-[(S)-1-(2,5-Dioxo-pyrrolidin-1-yloxycarbonyl)-ethylamino]-4-phenyl-butyric acid ethyl ester 
• 80828-33-7 (2S,3aS,7aS)-1-[(S)-2-((R)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-octahydro-indole-2-carboxylic acid tert-butyl ester 
• 80828-33-7 (2R,3aR,7aR)-1-[(S)-2-((R)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-octahydro-indole-2-carboxylic acid tert-butyl ester 
• 121209-29-8 7--(S)-alanyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid 
• 83507-88-4 7--(S)-alanyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid 

Relevant academic research and scientific papers

Purification method of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanine

The present invention is to provide a purification method of obtaining N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine of high quality in good yield with high productivity, which is accordingly suited for commercial scale application. An impurity-contaminated N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine is crystallized from a mixed solvent of alcohol and water in a volume ratio of alcohol/water being 1 to 20 to remove a contaminating impurity into a mother liquor and give crystals of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine.

A FAVOURABLE DIASTEREOSELECTIVE SYNTHESIS OF N-(1-S-ETHOXYCARBONYL-3-PHENYLPROPYL)-S-ALANINE

N-(1-S-Ethoxycarbonyl-3-phenylpropyl)-S-alanine is prepared by Michael addition of S-alaninebenzylester to ethyl-4-oxo-4-phenyl-2-butenoate in a regio- and diastereoselective fashion and subsequent catalytic hydrogenolysis.