93841-86-2

Upstream product

• 17831-01-5 H-Ala-OBzl 
• 82586-61-6 ethyl 2-bromo-4-phenylbutanoate 
• 90365-91-6 (-)-α-[(Trifluoromethyl)sulfonyl]oxy-4-phenylbutyric acid,ethyl ester 
• 1117-96-0 Diazoethan 
• 710-11-2 2-oxo-4-phenylbutyric acid 
• 5557-81-3 L-alanine benzyl ester hydrochloride 
• 93836-43-2 (R)-benzyl α-trifluoromethanesulphonyloxy propanoate 
• 124044-66-2 (R)-ethyl 2-amino-4-phenylbutanoate 
• 3017-53-6 benzyl 2-bromopropionate 
• 90891-21-7 L-(+)-α-amino-4-phenylbutyric acid ethyl ester hydrochloride 
• 5440-40-4 2-(acetylamino)-4-phenylbutanoic acid 
• 1012-05-1 D,L-homophenylalanine 
• 16503-46-1 2-bromo-4-phenyl butanoic acid 
• 100-51-6 benzyl alcohol 

Downstream Products

• 84324-12-9 N-<1(R)-(ethoxycarbonyl)-3-phenylpropyl>-(S)-alanine 
• 117560-16-4 (R)-2-((S)-1-Benzyloxycarbonyl-ethylamino)-4-phenyl-butyric acid ethyl ester; hydrochloride 
• 117605-22-8 (S)-3-[(R)-2-((S)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-1-methyl-2-oxo-imidazolidine-4-carboxylic acid tert-butyl ester 
• 89371-34-6 (S)-2-[(R)-1-(2,5-Dioxo-pyrrolidin-1-yloxycarbonyl)-ethylamino]-4-phenyl-butyric acid ethyl ester 
• 85196-26-5 (2R)-2-amino>propionic acid 
• 117605-19-3 (4S)-3-<(2R)-2-amino>propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylic acid 
• 111542-00-8 (S)-2-((R)-1-Benzyloxycarbonyl-ethylamino)-4-phenyl-butyric acid ethyl ester; hydrochloride 
• 130316-66-4 (2S)-3-aza-4-(ethoxycarbonyl)-2-methyl-6-phenylhexanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 877932-98-4 N-(1-ethoxycarbonyl-3-phenylpropyl)-L-alanine 

Relevant academic research and scientific papers

Nonpeptide Renin Inhibitors Employing a Novel 3-Aza(or oxa)-2,4-dialkyl Glutaric Acid Moiety as a P2/P3 Amide Bond Replacement

A new series of renin inhibitors has been developed.The inhibitors feature a novel replacement for the P2/P3 dipeptide moiety normally associated with renin inhibitors.The dipeptide replacement was a (2S,4S)-3-aza(or oxa)-2,4-dialkylglutaric acid amide.Ex

Studies on Angiotensin Converting Enzyme Inhibitors. 4. Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of 3-Acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic Acid Derivatives

(4S)-1-Alkyl-3-acyl>-2-oxoimidazolidine-4-carboxylic acid derivatives (3) were prepared by two methods.Their angiotensin converting enzyme (ACE) inhibitory activities and antihypertensive effects were evaluated, and the structure-activity relationships were discussed.The dicarboxylic acids 3a-n possessing S,S,S configuration showed potent in vitro ACE inhibitory activities with IC 50 values of 1.1x10-8-1.5x10-9 M.The most potent compound in this series, monoester 3p, had an ID 50 value of 0.24 mg/kg, po for inhibition of angiotensin I induced pressor response in normotensive rats and produced a dose-dependent decrease in systolic blood pressure of spontaneously hypertensive rats (SHRs) at doses of 1-10 mg/kg, po.

A Stereoselective Synthesis of N--L-alanine Derivatives by Means of Reductive Amination

A stereoselective synthesis of N--L-alanine, a portion of the molecule of angiotensin converting-enzyme(ACE) inhibitors, by reductive amination utilizing catecholborane and further applications of the reaction to the synthesis of ACE inhibitors are described.

Compounds for treating hypertension

Compounds of the formula STR1 and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.

Aromatic amino acid derivatives

A compound having the formula: STR1 wherein n is 0-5, inclusive; R1 is H or the identifying group of an amino acid; and R2 is H, aralkyl, or alkyl.

COMPOUNDS FOR TREATING HYPERTENSION

Compounds of the formula STR1 and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.

A FAVOURABLE DIASTEREOSELECTIVE SYNTHESIS OF N-(1-S-ETHOXYCARBONYL-3-PHENYLPROPYL)-S-ALANINE

N-(1-S-Ethoxycarbonyl-3-phenylpropyl)-S-alanine is prepared by Michael addition of S-alaninebenzylester to ethyl-4-oxo-4-phenyl-2-butenoate in a regio- and diastereoselective fashion and subsequent catalytic hydrogenolysis.

7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids

This invention relates to 7-carboxyalkyl-aminoacyl-1,4-adithia-7-azaspiro[4.4]nonane-8-carboxylic acids. The compounds of the invention are useful in the treatment of cardiovascular disorders and especially as antihypertensive agents.