124044-66-2

Basic information

• Product Name: D-Homophenylalanine ethyl ester
• Synonyms: D-Homophenylalanine ethyl ester;Benzenebutanoic acid, a-aMino-, ethyl ester, (aR)-
• CAS NO: 124044-66-2
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.271
• Mol File: 124044-66-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 311.4 °C at 760 mmHg
• Flash Point: 164.8 °C
• Appearance: /
• Density: 1.058
• CAS DataBase Reference: D-Homophenylalanine ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: D-Homophenylalanine ethyl ester(124044-66-2)
• EPA Substance Registry System: D-Homophenylalanine ethyl ester(124044-66-2)

Safety Data

• Hazardous Substances Data: 124044-66-2(Hazardous Substances Data)

Usage

General Description

D-Homophenylalanine ethyl ester is a chemical compound that belongs to the class of homophenylalanines, which are analogs of the amino acid phenylalanine. It is an ethyl ester derivative of D-homophenylalanine, and it is commonly used as a building block in the synthesis of peptide and protein-based pharmaceuticals. D-Homophenylalanine ethyl ester is important in the development of potential therapeutic agents and drug candidates, particularly in the field of medicinal chemistry and drug discovery. Its unique structure and properties make it a valuable reagent in the synthesis of various bioactive compounds and potential drug candidates targeting different disease conditions.

Upstream product

• 46460-23-5 ethyl L-2-amino-4-phenylbutyrate 
• 924-44-7 glyoxylic acid ethyl ester 
• 103-49-1 dibenzylamine 
• 64-17-5 ethanol 
• 82795-51-5 D-homophenylalanine 
• 100-42-5 styrene 
• 7064-04-2 ethyl 5-phenyl-2-isoxazoline-3-carboxylate 
• 591-50-4 iodobenzene 
• 22621-37-0 ethyl 2-aminobutyrate 
• 1012-05-1 D,L-homophenylalanine 
• 67753-90-6 9-phenethyl-9-bora-bicyclo[3.3.1]nonane 
• 940290-40-4 ethyl 2-((4-methoxyphenyl)amino)-4-phenylbutanoate 
• 22326-34-7 2-amino-4-oxo-4-phenyl-2-butenoic acid ethyl ester 
• 188530-97-4 ethyl 3-[(p-nitrobenzenesulfonyl)oxy]-2-oxo-4-phenylbutanoate 

Downstream Products

• 1195164-50-1 N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide 
• 102609-80-3 2-((1S,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yloxycarbonylamino)-4-phenyl-butyric acid ethyl ester 
• 64920-29-2 2-oxo-4-phenylbutanoic acid ethyl ester 
• 93841-86-2 N-<1(R)-(Ethoxycarbonyl)-3-phenylpropyl>-(S)-alanin-benzylester 
• 84324-12-9 N-<1(R)-(ethoxycarbonyl)-3-phenylpropyl>-(S)-alanine 
• 122076-80-6 N-<1(R)-(Ethoxycarbonyl)-3-phenylpropyl>-(R)-alanin 
• 105382-09-0 (R)-2-amino-4-phenylbutanoic acid hydrochloride 
• 1151509-66-8 2-(3-benzo[1,3]dioxol-5-yl-2-hydroxy-propionylamino)-4-phenyl-butyric acid ethyl ester 
• 943-73-7 D-homophenylalanine 
• 82795-51-5 D-homophenylalanine 
• 1012-05-1 D,L-homophenylalanine 
• 160886-95-3 (RS)-2-amino-4-phenylbutan-1-ol 
• 39645-19-7 Ethyl 2-benzamido-4-phenylbutyrate 
• 1233345-51-1 ethyl 2-[3-(4-benzoylphenylamino)-3-oxopropanamido]-4-phenylbutanoate 

Relevant articles and documents

Asymmetric Synthesis of N-Substituted α-Amino Esters from α-Ketoesters via Imine Reductase-Catalyzed Reductive Amination

N-Substituted α-amino esters are widely used as chiral intermediates in a range of pharmaceuticals. Here we report the enantioselective biocatalyic synthesis of N-substituted α-amino esters through the direct reductive coupling of α-ketoesters and amines employing sequence diverse metagenomic imine reductases (IREDs). Both enantiomers of N-substituted α-amino esters were obtained with high conversion and excellent enantioselectivity under mild reaction conditions. In addition >20 different preparative scale transformations were performed highlighting the scalability of this system.

IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS

The present invention is in the field of bioluminescence in biology and/or medicine. In particular, the invention provides imidazopyrazine derivatives, processes for preparation thereof, and their uses as luciferins.

Copper-Catalyzed Addition of Alkylboranes to Iminoacetates: Access to α-Alkyl Branched α-Amino Acids

A copper(I)-catalyzed addition of alkylborane reagents to α-iminoacetates has been developed to assemble both acyclic and cyclic α-branched α-amino carboxylic acid derivatives in good yields. A wide variety of unactivated alkenes are well tolerated in this transformation. (Figure presented.).