84325-97-3

Upstream product

• 17639-93-9 2-chloro-propionic acid methyl ester 
• 99-90-1 para-bromoacetophenone 
• 67-56-1 methanol 
• 112921-88-7 1-(4-(prop-1-yn-1-yl)phenyl)ethan-1-one 

Downstream Products

• 84326-11-4 2-[4-(6-Nitro-2-oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-propionic acid methyl ester 
• 84326-13-6 2-[4-(6,8-Dimethyl-2-oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-propionic acid methyl ester 
• 84326-09-0 2-[4-(6-Chloro-2-oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-propionic acid methyl ester 
• 84326-12-5 2-[4-(8-Chloro-2-oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-propionic acid methyl ester 
• 84326-10-3 2-[4-(6-Methyl-2-oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-propionic acid methyl ester 
• 84326-08-9 Methyl 4-(2H-1,4-benzoxazin-2-one-3-yl)phenyl-α-methylacetate 
• 84326-01-2 2-(4-Ethoxyoxalyl-phenyl)-propionic acid methyl ester 
• 84325-99-5 2-[4-(2-Bromo-acetyl)-phenyl]-propionic acid methyl ester 
• 41387-29-5 2-[4-(acetyl)phenyl] propanoic acid 

Relevant academic research and scientific papers

Oxidative Rearrangement of Alkynes to Carboxylic Acid Esters by benzene in Methanol

A direct synthesis of methyl aryl alkanoate via oxidative rearrangement of alkynes using benzene in methanol is described.

Ni-Catalyzed Reductive C-O Bond Arylation of Oxalates Derived from α-Hydroxy Esters with Aryl Halides

A Ni-catalyzed reductive cross-coupling of α-hydroxycarbonyl compounds modified with oxalyl groups and aryl halides has been developed that furnishes α-aryl esters under mild conditions and tolerates a variety of functionalized aryl halides bearing electron-withdrawing and -donating groups. This work highlights C-O bond fragmentation on secondary alkyl carbon centers that generates α-carbonyl radicals.

Ni-catalyzed activation of α-chloroesters: a simple method for the synthesis of α-arylesters and β-hydroxyesters

Coupling reactions of α-chloroesters with aryl halides (α-arylation) or carbonyl compounds (Reformatsky) using nickel catalyst allow, under mild conditions, the preparation of various functionalized aryl propionic acid derivatives or β-hydroxyesters. In the synthesis of aryl propionic acid derivatives, the process is efficient with aryl halides bearing either electron-withdrawing or electron-donating groups.