844-87-1

Upstream product

• 22864-65-9 N-methyl-4-(trifluoromethyl)aniline 
• 611-73-4 Benzoylformic acid 
• 91385-14-7 N-methyl-N-(4-(trifluoromethyl)phenyl)nitrous amide 
• 108-88-3 toluene 
• 328-87-0 2-chloro-5-(trifluoromethyl)benzonitrile 
• 789-96-8 (2-chloro-5-(trifluoromethyl)phenyl)(phenyl)methanone 
• 74-89-5 methylamine 

Relevant academic research and scientific papers

Method for synthesizing 2-aminobenzophenone compound

The invention discloses a method for synthesizing a 2-aminobenzophenone compound, and belongs to the technical field of organic synthesis. According to the key point of the technical scheme, the method comprises the following steps that an N-nitroso-2-ami

Synthesis of 2-aminobenzophenones through acylation of anilines with α-oxocarboxylic acids assisted by: Tert -butyl nitrite

In this paper, a regioselective, efficient and convenient synthesis of 2-aminobenzophenones through acylation of anilines with α-oxocarboxylic acids assisted by tert-butyl nitrite is presented. Interestingly, tert-butyl nitrite acts as not only an efficient and mild nitrosation reagent, but also a sustainable oxidant required in the Pd(ii)-catalyzed decarboxylative acylation. Meanwhile, the NO unit turned out to be an easily introduced and readily removable directing group for the regioselective acylation.

Palladium-catalyzed oxidative C-H bond acylation of N-nitrosoanilines with toluene derivatives: A traceless approach to synthesize N-alkyl-2-aminobenzophenones

A palladium-catalyzed cascade cross-coupling of N-nitroso-anilines and toluene derivatives for the direct synthesis of N-alkyl-2-aminobenzophenones is described. N-nitroso groups in anilines can act as the traceless directing groups while toluene derivatives can serve as effective acyl precursors under mild reaction conditions.