84379-52-2

Basic information

• Product Name: (-)-2-O-BENZYL-D-THREITOL
• Synonyms: (2R,3R)-(-)-2-BENZYLOXY-1,3,4-BUTANETRIOL;(2R,3R)-3-(PhenylMethoxy)-1,2,4-butanetriol;(-)-2-O-BENZYL-D-THREITOL
• CAS NO: 84379-52-2
• Molecular Formula: C₁₁H₁₆O₄
• Molecular Weight: 212.24
• Mol File: 84379-52-2.mol
• Article Data: 30

Chemical Properties

• Melting Point: 75-77 °C
• Boiling Point: 424.1°C at 760 mmHg
• Flash Point: 210.3°C
• Appearance: /
• Density: 1.238g/cm³
• Vapor Pressure: 6.01E-08mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (-)-2-O-BENZYL-D-THREITOL(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-2-O-BENZYL-D-THREITOL(84379-52-2)
• EPA Substance Registry System: (-)-2-O-BENZYL-D-THREITOL(84379-52-2)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 3-9
• Hazardous Substances Data: 84379-52-2(Hazardous Substances Data)

Usage

General Description

(-)-2-O-benzyl-D-threitol is a compound with a molecular formula of C14H18O2. It is a chiral, organic compound that belongs to the family of alcohols. (-)-2-O-BENZYL-D-THREITOL is characterized by its benzyl group and hydroxyl functional groups, which impart both reactivity and solubility. (-)-2-O-benzyl-D-threitol is commonly used in organic synthesis as a chiral building block, particularly in the production of pharmaceuticals and biologically active molecules. It is also utilized in the preparation of various chiral ligands and catalysts for asymmetric synthesis. Additionally, this compound has potential applications in the field of materials science and as a chiral resolving agent in analytical chemistry.

InChI:InChI=1/C11H16O4/c12-6-10(14)11(7-13)15-8-9-4-2-1-3-5-9/h1-5,10-14H,6-8H2/t10-,11-/m1/s1

Upstream product

• 141042-56-0 diethyl(4S,5S)-2-phenyl-1,3-dioxolan-4,5-dicarboxylate 
• 1450667-23-8 C₂₅H₂₆O₃Si 
• 1450667-24-9 C₂₃H₂₄O₂Si 
• 100-52-7 benzaldehyde 
• 38270-70-1 dimethyl meso-2,3-O-benzylidenetartrate 
• 21154-16-5 (4R,5R)-2-Phenyl-[1,3]dioxolane-4,5-dicarboxylic acid diethyl ester 
• 608-68-4 dimethyl L-tartrate 
• 91326-83-9 (4S,5S)-dimethyl 2-phenyl-1,3-dioxolane-4,5-dicarboxylate 
• 104333-70-2 (2R,3R)-2-benzyloxy-3-hydroxy-1,4-butanedioic acid dimethyl ester 
• 119770-87-5 (2R,3R)-diethyl 2-(benzyloxy)-3-hydroxysuccinate 
• 100-39-0 benzyl bromide 
• 35572-31-7 (4R,5R)-2-Phenyl-1,3-dioxolan-4,5-dicarbonsaeure-diethylester 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 87-91-2 diethyl (2R,3R)-tartrate 

Downstream Products

• 94451-15-7 4-O-benzoyl-2-O-benzyl-1,2-O-isopropylidene-L-threitol 
• 194283-76-6 4-O-benzoyl-2-O-benzyl-L-threitol 
• 194283-77-7 Benzoic acid (2S,3S)-2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-butyl ester 
• 194283-82-4 (E)-3-[(1S,2R)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-oxo-propoxy]-acrylic acid methyl ester 
• 194283-79-9 (E)-3-[(1S,2S)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-propoxy]-acrylic acid methyl ester 
• 194283-78-8 Benzoic acid (2S,3S)-2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-3-((E)-2-methoxycarbonyl-vinyloxy)-butyl ester 
• 165545-36-8 (2S,4R,5R)-5-Benzyloxy-2-phenyl-4-(2,2,2-trichloro-ethyl)-[1,3]dioxane 
• 89157-42-6 1-O-hexadecyl-2-O-benzyl-D-glyceraldehyde 
• 84379-57-7 1-O-hexadecyl-2-O-benzyl-D-threitol 
• 84379-55-5 1-O-hexadecyl-2-O-benzyl-3,4-O-isopropylidene-D-threitol 
• 84415-89-4 (S)-2-benzyloxy-3-hexadecyloxy-propan-1-ol 
• 91326-84-0 1-O-hexadecyl-2-O-benzyl-sn-glycero-3-phosphocholine 
• 91274-00-9 2-bromoethyl 2-O-benzyl-L-1-O-hexadecyl-glyceryl hydrogen phosphate 
• 80459-32-1 (2R)-2-Benzyloxy-3-octadecyloxypropyl 2-bromoethyl phosphate 

Relevant articles and documents

Studies toward the total synthesis of amphidinolide n: stereocontrolled synthesis of the c13-c29 segment

A stereocontrolled synthesis of the C13-C29 segment of amphidinolide N, a marine macrolide natural product that is extremely potent cytotoxic, is described.

EP300/CREBBP INHIBITOR

The present invention provides a compound having excellent histone acetyltransferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q1, ring Q2, R1, R2, R3 and R4 respectively have the same meanings as defined in the specification.

Reaction of (2S,3S)-2-benzyloxybutane-1,2,4-triol with N,N′-carbonyldiimidazole

(2S,3S)-2-Benzyloxybutane-1,2,4-triol reacted with N,N′-carbonyldiimidazole to give a mixture of the expected 1,2-carbonate and the corresponding bis-carbonate.