91326-83-9

Usage

InChI:InChI=1/C12H12O6/c1-16-11(15)9-8(10(13)14)17-12(18-9)7-5-3-2-4-6-7/h2-6,8-9,12H,1H3,(H,13,14)/t8-,9-,12?/m0/s1

Upstream product

• 608-68-4 dimethyl L-tartrate 
• 100-52-7 benzaldehyde 
• 7527-52-8 2-phenyl-1,3-benzodioxole 
• 13171-64-7 Dimethyl D-tartrate 
• 147-71-7 D-tartaric acid 
• 149-73-5 trimethyl orthoformate 
• 4362-19-0 deoxybenzoin ethylene glycol acetal 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 608-69-5 dimethyl meso-tartrate 
• 67-56-1 methanol 
• 451-40-1 phenyl benzyl ketone 
• 167862-20-6 5-methyl-2-phenyl-1,3-dioxolan-4-one 
• 64714-16-5 2-phenyl-4,5-trans-tetrametylene-1,3-dioxolan 
• 608-68-4 dimethyl D-(+)-tartrate 

Downstream Products

• 92056-07-0 (4R,5R)-4,5-bis(methoxycarbonyl)-2-(2-nitrophenyl)-1,3-dioxolane 
• 141042-56-0 diethyl(4S,5S)-2-phenyl-1,3-dioxolan-4,5-dicarboxylate 
• 1456695-39-8 (R)-4-[(R)-1-(benzyloxy)allyl]-2,2-diethyl-1,3-dioxolane 
• 84379-51-1 2-O-benzyl-L-threitol 
• 115689-97-9 1-methanesulfonyloxy-2-O-benzyl-3,4-O-isopropylidene-D-threitol 
• 115689-96-8 (2R,3S)-3-O-benzyl-4-iodo-1,2-O-isopropylidenebutane-1,2,3-triol 
• 100906-43-2 (Z,S,S)-methyl 4-O-benzyl-5,6-di-O-isopropylidene-4,5,6-trihydroxy-2-hexenoate 
• 100906-41-0 (5S,6S)-5-(benzyloxy)-6-(hydroxymethyl)-5,6-dihydro-2H-pyran-2-one 
• 100906-42-1 2-O-benzyl-3,4-O-isopropylidene-L-threose 
• 100906-44-3 (Z)-4-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-enoic acid 
• 100906-45-4 (5R,6S)-6-Benzyloxy-2,2-dimethyl-[1,3]dioxepan-5-ol 
• 100906-46-5 [(4'S,5'S)-5'-(benzyloxy)-2',2'-dimethyl-1',3'-dioxan-4'-yl]methanol 
• 100906-47-6 (Z)-2-Benzyloxy-4-hydroxy-but-2-enal 
• 84379-53-3 2-O-benzyl-3,4-O-isopropylidene-L-threitol 

Relevant academic research and scientific papers

Posaconazole derivative, pharmaceutical composition and use thereof

The present disclosure provides a posaconazole derivative, a pharmaceutical composition and use thereof, which specifically include a compound represented by the following formula (I), a racemate, stereoisomer, tautomer, oxynitride, or a pharmaceutically acceptable salt thereof: The compounds of the present disclosure have strong antifungal activity, high safety, and good water solubility, without the need for the addition of a cosolvent (such as hydroxypropyl-β-cyclodextrin, sulfobutyl ether-β-cyclodextrin, and the like) with potential safety risks. Furthermore, the formulation process of the compound could have less difficulty and less cost, and therefore can be used to prepare improved antifungal drugs.

Production of optically active 2 - vinylcyclopropane - 1, 1 - dicarboxylic acid ester

Provided is a method for producing an optically active 1-amino-2-vinylcyclopropane-1-carboxylic acid ester and 2-vinylcyclopropane-1,1-dicarboxylic acid ester, which do not isomerize during a reaction, with an inexpensive and easily obtainable optically a

Enantioselective construction of 6-substituted-α,β-unsaturated- δ-lactone: Total synthesis of anti-bacterial agent (-)-cleistenolide

An efficient and straightforward stereoselective synthesis of α,β-unsaturated lactone (1) cleistenolide is described. The synthesis was started from commercially available d-tartaric acid and completed within 13 steps with an overall yield of 7.92%. The cis-olefin was generated from Still-Gennari protocol and one of the hydroxyl groups was from dihydroxylation methodology. All the reactions were very clean and the products were obtained in very good yields.

Synthesis of L-lyxo-phytosphingosine and its 1-phosphonate analogue using a threitol acetal synthon

The first synthesis of an isosteric phosphonate analogue of the aminotriol lipid phytosphingosine (3), together with an improved synthesis of (2S,3S,4S)-phytosphingosine (2), are described. A key intermediate is 3-pentylidene acetal 9, which was prepared in two steps from dimethyl 2,3-0-benzylidene-D-tartrate (7).

Aromatic Nitration under Neutral Conditions Using Nitrogen Dioxide and Ozone as the Nitrating Agent. Application to Aromatic Acetals and Acylal

Cyclic acetals derived from aromatic carbonyl compounds can be nitrated smoothly with nitrogen dioxide in ice-cooled dichloromethane or acetonitrile in the presence of ozone and magnesium oxide to give ortho- and para-nitro derivatives as the major product in good combined yields, the acetal ring as a protective group remaining almost intact.An acylal derived from benzaldehyde similarly undergoes nitration on the aromatic ring to give an isomeric mixture of three nitro compounds, in which the ortho and meta isomers predominate, while aromatic orthoesters are rapidly decomposed to give simply the parent esters.Ring nitration under neutral conditions has been interpreted in terms of a nonclassical mechanism, in which nitrogen trioxide is involved as the initial electrophile.

A one-pot synthesis of dimethyl 2,3-O-benzylidene-L-tartrate from L- tartaric acid

An economical one-pot synthesis of (-)-dimethyl 2,3-O-benzylidene-L- tartrate [(4R,5S)-4,5-bis(methoxycarbonyl)-2-phenyl-1,3-dioxolane] and its enantiomer from the corresponding tartaric acids is reported in 83-91% yield. The desired benzylidene tartrate

THE USE OF L-TARTARIC ACID IN THE SYNTHESIS OF ENANTIOMERICALLY PURE COMPOUNDS: SYNTHESIS OF 4-O-BENZYL-2,3-DIDEOXI-L-THREO-HEX-2-ENONO-1,5-LACTONE

The title compound was obtained through a seven steps sequence and using -dimethyl L-tartrate as the starting material (30percent overall yield).The system 2,3-dideoxy-L-threo-hex-2-enono-1,5-lactone is present in several natural compounds.

AN EFFICIENT AND STEREOSELECTIVE SYNTHESIS OF PLATELET-ACTIVATING FACTORS AND THE ENANTIOMERS FROM D- AND L-TARTARIC ACIDS

Acetyl glyceryl ether phosphorylcholines, platelet-activating factors (1 and 2), were efficiently synthesized in a stereochemically unambiguous manner starting from D- and L- tartaric acids as the chiral synthons.