84449-64-9

Usage

Uses

Used in Organic Synthesis:
2-[4-(Benzoyloxy)phenyl]benzo[b]thiophene-6-ol 6-benzoate is used as a starting material in organic synthesis for the creation of various pharmaceutical intermediates and organic compounds. Its unique structure allows for the development of new chemical entities with diverse applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-[4-(Benzoyloxy)phenyl]benzo[b]thiophene-6-ol 6-benzoate is used as a precursor for the synthesis of potential therapeutic agents. Its structural features may contribute to the discovery of new drugs with novel mechanisms of action or improved pharmacological properties.
Used in Materials Science:
2-[4-(Benzoyloxy)phenyl]benzo[b]thiophene-6-ol 6-benzoate is utilized in materials science for the development of new materials with specific properties or functions. Its structural characteristics may enable the creation of materials with tailored characteristics for use in various applications, such as sensors, optoelectronics, or advanced coatings.
While the specific biological activities or therapeutic effects of 2-[4-(Benzoyloxy)phenyl]benzo[b]thiophene-6-ol 6-benzoate have not been detailed in the provided materials, its potential in the pharmaceutical industry suggests that further research could uncover valuable medicinal properties.

InChI:InChI=1S/C28H18O4S/c29-27(20-7-3-1-4-8-20)31-23-14-11-19(12-15-23)25-17-22-13-16-24(18-26(22)33-25)32-28(30)21-9-5-2-6-10-21/h1-18H

Upstream product

• 98-88-4 benzoyl chloride 
• 63676-22-2 6-hydroxy-2-(4-hydroxyphenyl)benzo[B]-thiophene 
• 15570-12-4 3-methoxybenzenethiol 
• 63675-73-0 α-(3-methoxyphenyl-thio)-4-methoxyacetophenone 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Downstream Products

• 84449-83-2 6-benzoyloxy-2-(4-benzoyloxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene, hydrochloride 
• 84449-69-4 <6-(benzoyloxy)-2-<4-(benzoyloxy)phenyl>benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride 
• 63676-25-5 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-pyrrolidinoethoxy)benzoyl]benzo[b]thiophene 

Relevant academic research and scientific papers

2-arylbenzo[B]thiophenes useful for the treatment of estrogen deprivation syndrome

This invention provides methods which are useful for the inhibition of the various medical conditions associated with estrogen deprivation syndrome including osteoporosis and hyperlipidemia utilizing compounds of formula I:

Antiestrogens. 2. Structure-Activity Studies in a Series of 3-Aroyl-2-arylbenzothiophene Derivatives Leading to thien-3-yl>phenyl>methanone Hydrochloride (LY156758), a Remarkably Effective Estrogen Antagonist with On...

In an effort to prepare nonsteroidal antiestrogens demonstrating greater antagonism and less intrinsic estrogenicity than those currently available, a series of 3-aroyl-2-arylbenzothiophene derivatives was synthesized.These compounds were prepared by Friedel-Crafts aroylation of appropriate O-protected 2-arylbenzothiophene nuclei with basic side-chain-bearing benzoyl chlorides followed by removal of the protective groups to provide the desired compounds containing both hydroxyl and basic side-chain functionality.A particularly useful method for the cleavage of aryl methoxy ethers without removal of (dialkylamino)ethoxy side chain functionality elsewhere in the molecule was found to be AlCl3/EtSH.The benzothiophene derivatives were tested for their ability to inhibit the growth-stimulating action of estradiol on the immature rat uterus.Seemingly minor changes in the side-chain amine moiety were found to have profound effects on the ability of the compounds to antagonize estradiol.Analogues having basic side chains containing cyclic (pyrrolidine, piperidine, and hexamethyleneamine) moieties were found to have less intrinsic estrogenicity and to antagonize estradiol action more completely than their noncyclic counterparts.The most effective antiestrogen in the series, compound 44, thien-3-yl>phenyl>methanone, elicited a modest uterotropic activity that did not increase with increasing dose.In antagonism of estradiol, 44 exhibited a degree of inhibition surpassing that of tamoxifen at any dose tested.The new benzothiophene antiestrogen was also shown to have high affinity for rat uterine cycloplasmic estrogen receptor and to be an inhibitor of the growth of DMBA-induced rat mammary tumors.