84456-99-5Relevant academic research and scientific papers
Direct Annulation of Hydrazides to 1,3,4-Oxadiazoles via Oxidative C(CO)-C(Methyl) Bond Cleavage of Methyl Ketones
Gao, Qinghe,Liu, Shan,Wu, Xia,Zhang, Jingjing,Wu, Anxin
supporting information, p. 2960 - 2963 (2015/06/30)
A new strategy for the synthesis of 1,3,4-oxadiazoles was established through direct annulation of hydrazides with methyl ketones. It was found that the use of K2CO3 as a base achieves an unexpected and highly efficient C-C bond clea
Pd-Catalyzed Csp2-H Functionalization of Heteroarenes via Isocyanide Insertion: Concise Synthesis of Di-(Hetero)Aryl Ketones and Di-(Hetero)Aryl Alkylamines
Sharma, Upendra K.,Sharma, Nandini,Xu, Jun,Song, Gonghua,Van Der Eycken, Erik V.
supporting information, p. 4908 - 4912 (2015/03/30)
We report herein an efficient Pd-catalyzed direct C-H bond functionalization of heteroarenes via an isocyanide insertion strategy for the synthesis of di-(hetero)aryl ketones and di-(hetero)aryl alkylamines. The methodology involves a three component reaction between an azole, a haloarene and an isocyanide resulting in the formation of an imine, which in turn is either hydrolyzed or reduced to get the desired product.
A facile and expeditious one-pot synthesis of α-Keto-1,3,4- oxadiazoles
Kumar, Dalip,Pilania, Meenakshi,Arun,Mishra, Bhupendra
, p. 1137 - 1141 (2014/05/20)
An efficient and high-yielding protocol for the preparation of α-keto-1,3,4-oxadiazoles has been developed. Formation of α-keto-1,3,4-oxadiazoles involves the 2-iodoxybenzoic acid/ tetraethylammonium bromide mediated oxidative cyclization of hydrazide-hyd
A novel one-pot synthesis of α-keto-1,3,4-oxadiazole derivatives based on isocyanide-Nef reaction
Cui, Liren,Liu, Qiong,Yu, Jingxun,Ni, Chongzhi,Yu, Hui
experimental part, p. 5530 - 5533 (2011/11/05)
Various α-keto-1,3,4-oxadiazole derivatives were synthesized through a sequential intermolecular dehydrochlorination/intramolecular aza-Wittig reaction of carboxylic acids and imidoyl chloride intermediates, which were generated by isocyanide-Nef reaction
TETRAZOLES IN THE SYNTHESES OF 1,3,4-OXADIAZOLES
Koldobskii, G. I.,Ivanova, S. E.
, p. 1512 - 1517 (2007/10/03)
Various variants of cleavage of tetrazoles to form 1,3,4-oxadiazoles are examined.The mechanisms and synthetic potentialities of these reactions are discussed.
