844857-08-5

Upstream product

• 139183-60-1 N-t-butoxylcarbonyl-O-methyl-L-tyrosinal 
• 844856-98-0 [2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester 
• 844856-99-1 2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethylamine 
• 844856-94-6 [2-hydroxy-1-(4-methoxybenzyl)-2-(8-oxo-1,4-dioxaspiro[4.5]dec-7-yl)ethyl]carbamic acid tert-butyl ester 
• 844856-96-8 [2-hydroxy-2-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester 
• 100-39-0 benzyl bromide 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Relevant academic research and scientific papers

A formal total synthesis of (-)-FR901483, using a tandem cationic aza-Cope rearrangement/Mannich cyclization approach

(Chemical Equation Presented) A formal total synthesis of the immunosuppressant FR901483 has been accomplished. The key step in the synthesis utilizes a tandem cationic aza-Cope rearrangement/Mannich cyclization reaction for accessing the unprecedented br