844857-13-2

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 844856-96-8 [2-hydroxy-2-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester 
• 844856-94-6 [2-hydroxy-1-(4-methoxybenzyl)-2-(8-oxo-1,4-dioxaspiro[4.5]dec-7-yl)ethyl]carbamic acid tert-butyl ester 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 844857-25-6 N-[7,9-bisbenzyloxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodec-3-yl]-N-methylcarbamic acid tert-butyl ester 
• 844857-09-6 (1S,3S,6S,7S,8S,9S)-7,9-Bis-benzyloxy-6-(4-methoxy-benzyl)-5-aza-tricyclo[6.3.1.0^1,5]dodecane-3-carbonyl azide 
• 844856-98-0 [2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester 
• 844857-12-1 [7,9-bisbenzyloxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodec-3-yl]carbamic acid methyl ester 
• 844857-11-0 7,9-bisbenzyloxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodecane-3-carboxylic acid 
• 844857-14-3 [7,9-bisbenzyloxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodec-3-yl]methanol 
• 844857-10-9 [7,9-bisbenzyloxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodec-3-yl](methyl)amine 
• 844856-99-1 2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethylamine 
• 139183-60-1 N-t-butoxylcarbonyl-O-methyl-L-tyrosinal 

Downstream Products

• 327037-84-3 N-[9-(bisbenzyloxyphosphoryloxy)-7-hydroxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodec-3-yl]-N-methylcarbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Total synthesis of FR901483

(Chemical Equation Presented) The architecturally sophisticated skeleton of the immurtosuppressfve alkaloid FR901483 was assembled via a process relying on the reaction of an in situ generated !mine with a suitably disposed donor-acceptor cyclopropane. A

A formal total synthesis of (-)-FR901483, using a tandem cationic aza-Cope rearrangement/Mannich cyclization approach

(Chemical Equation Presented) A formal total synthesis of the immunosuppressant FR901483 has been accomplished. The key step in the synthesis utilizes a tandem cationic aza-Cope rearrangement/Mannich cyclization reaction for accessing the unprecedented br