84543-50-0Relevant academic research and scientific papers
Cu(OTf)2-Catalyzed Pummerer Coupling of β-Ketosulfoxides
Parnes, Regev,Reiss, Hagai,Pappo, Doron
, p. 723 - 732 (2018/01/28)
The copper(II) trifluoromethanesulfonate-catalyzed Pummerer reaction of β-ketosulfoxides with 1,3-dicarbonyl compounds or π-nucleophiles such as phenols, arenes, and tetraallylsilane is reported. The mild conditions provide an efficient entry to a novel class of polysubstituted 3-alkylthiofuran and polysubstituted 3-thiobenzofuran heterocycles from readily available materials.
Weinreb amide based building blocks for convenient access to 1,1-diarylethenes and isocombretastatin analogues
Balasubramaniam, Sivaraman,Kommidi, Harikrishna,Aidhen, Indrapal Singh
supporting information; experimental part, p. 2683 - 2686 (2011/06/19)
A successful strategy based on the synthetic equivalent containing Weinreb amide functionality for the convenient access to 1,1-diarylethenes in general and for the isocombretastatin analogues in particular has been developed from the commercially available glyoxalic acid. The convenience with which the structural variations can be made in assembling the aryl residues shows generality associated with the developed strategy. The intermediates also provide access to 1,2,2-triarylethanones, represented by the synthesis of advanced intermediate of tamoxifen.
Isomerization of Trimethyl α-Keto Trithioorthocarboxylates into α,α-Bis(methylthio) Thiolcarboxylates. A New Rearrangement of Synthetic Interest
Degani, Iacopo,Dughera, Stefano,Fochi, Rita,Gazzetto, Sonia
, p. 7228 - 7233 (2007/10/03)
A study was made of the isomerization reaction of a great variety of trimethyl α-keto trithioorthocarboxylates to α,α-bis(methylthio) thiolcarboxylates, intermediates of high synthetic value for the synthesis of α-arylpropionic acids. The reaction was carried out in methylene chloride in the presence of catalytic amounts of trityl perchlorate or methanesulfonic acid and was complete in 2 h at rt. In most of the investigated cases the result was positive, the yields usually being greater than 90%. Also the reaction mechanism was subjected to an experimental study.
On the Control of Sulphenylations at Carbon
Grossert, J. Stuart,Dubey, Pramod K.
, p. 1183 - 1184 (2007/10/02)
Controlled monosulphenylation at carbon adjacent to electron-withdrawing groups can be achieved by the controlled reduction of readily available bis-sulphenylated products.
