84545-14-2

Basic information

• Product Name: Benzamide, 4-(chloromethyl)- (9CI)
• Synonyms: Benzamide, 4-(chloromethyl)- (9CI);benzamide, 4-(chloromethyl)-;4-(chloromethyl)benzamide(SALTDATA: FREE);alpha-Chloro-p-toluamide
• CAS NO: 84545-14-2
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.60822
• Product Categories: HALOMETYL
• Mol File: 84545-14-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 327.4°C at 760 mmHg
• Flash Point: 151.8°C
• Appearance: /
• Density: 1.248g/cm³
• Vapor Pressure: 0.000202mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: Benzamide, 4-(chloromethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-(chloromethyl)- (9CI)(84545-14-2)
• EPA Substance Registry System: Benzamide, 4-(chloromethyl)- (9CI)(84545-14-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 84545-14-2(Hazardous Substances Data)

Usage

General Description

Benzamide, 4-(chloromethyl)- (9CI) is a chemical compound that belongs to the benzamide class of compounds. It is derived from benzene and contains a chloromethyl group attached to the 4-position of the benzene ring. Benzamide, 4-(chloromethyl)- (9CI) is primarily used in organic synthesis as a starting material for the production of other organic compounds. It can also be used in pharmaceutical research and as an intermediate in the manufacturing of various chemical products. Additionally, it may have potential applications in the field of medicinal chemistry for the development of new drugs. However, it is important to handle this compound with care as it may pose health and environmental hazards.

InChI:InChI=1/C8H8ClNO/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4H,5H2,(H2,10,11)

Upstream product

• 876-08-4 p-(chloromethyl)benzoyl chloride 
• 1603-91-4 4-methylthiazol-2-ylamine 
• 1642-81-5 p-(chloromethyl)benzoic acid 
• 551-93-9 2-aminoacetophenone 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 515131-55-2 4-dimethylaminomethyl-benzoic acid amide 
• 864528-53-0 4-(azidomethyl)benzamide 
• 54589-57-0 p-(N,N-diethylcarbamoyl)benzyl chloride 
• 6051-41-8 4-formylbenzamide 
• 1421044-91-8 4-((4-(6-(mesityloxy)-3-nitropyridin-2-yl-amino)piperidin-1-yl)methyl)benzamide 
• 1421044-99-6 4-((4-(6-(4-cyano-2,6-dimethylphenoxy)-3-nitropyridin-2-yl-amino)piperidin-1-yl)methyl)benzamide 
• 1421045-10-4 4-((4-(6-(mesitylamino)-3-nitropyridin-2-yl-amino)piperidin-1-yl)methyl)benzamide 
• 1421045-03-5 4-((4-(3-amino-6-(4-cyano-2,6-dimethylphenoxy)pyridin-2-ylamino)piperidin-1-yl)methyl)benzamide 
• 1421044-95-2 4-((4-(3-amino-6-(mesityloxy)pyridin-2-ylamino)piperidin-1-yl)methyl)benzamide 
• 1381770-31-5 4-((4-(4-amino-6-(mesitylamino)-1,3,5-triazin-2-ylamino)piperidin-1-yl)methyl)benzamide 
• 1381770-44-0 4-((4-(4-(mesitylamino)-6-methoxy-1,3,5-triazin-2-ylamino)piperidin-1-yl)methyl)benzamide 
• 1381770-39-3 4-((4-(4-(mesitylamino)-6-(methylamino)-1,3,5-triazin-2-ylamino)piperidin-1-yl)methyl)benzamide 
• 1240518-29-9 4-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}benzamide 
• 84545-15-3 4-[3-nitropyrazol-1-ylmethyl]benzamide 

Relevant articles and documents

Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity

SCD1 is a rate-limiting enzyme in the conversion of saturated fatty acids to monounsaturated fatty acids. SCD1 inhibitors have potential effects on obesity, diabetes, acne, and cancer, but the adverse effects associated with SCD1 inhibition in the skin and eyelids are impediments to clinical development. To avoid mechanism-based adverse effects, we explored the compounds that selectively inhibit SCD1 in the liver in an ex vivo assay. Starting from a systemically active lead compound, we focused on the physicochemical properties tPSA and cLogP to minimize exposure in the off-target tissues. This effort led to the discovery of thiazole-4-acetic acid analog 48 as a potent and liver-selective SCD1 inhibitor. Compound 48 exhibited significant effects in rodent models of diabetes, hepatic steatosis, and obesity, with sufficient safety margins in a rat toxicology study with repeated dosing.

PROCESS FOR PREPARATION OF BENZYLPIPERIDINE COMPOUNDS

According to the process as shown in the following scheme having a step for reacting Compound (I) with Compound (II) to produce Compound (III), benzylpiperidine compounds useful as synthesis starting materials of pharmaceutical agents, agricultural chemicals and the like can be produced conveniently by a short step: wherein R1 is a hydrogen atom or an amino-protecting group, R2 is a hydrogen atom, a hydrocarbon group optionally having substituents, an alkoxy group optionally having substituents or a heterocyclic group optionally having substituents, and R3 is a lower alkyl group.