84547-61-5

Usage

Uses

Used in Pharmaceutical Synthesis:
5-(Hydroxymethyl)-1-methyl-1H-pyrazole is used as a reagent in the pharmaceutical industry for the synthesis of various drugs. Its unique chemical structure allows it to participate in a range of reactions, contributing to the development of new and effective medications.
Used in Agrochemical Production:
In the agrochemical sector, 5-(Hydroxymethyl)-1-methyl-1H-pyrazole is utilized as a key component in the synthesis of pesticides and other agricultural chemicals. Its involvement in these reactions helps to create products that protect crops and enhance agricultural productivity.
Used in Polymer Production:
5-(Hydroxymethyl)-1-methyl-1H-pyrazole is employed as a reagent in the production of polymers. Its chemical properties make it suitable for use in the synthesis of polymers with specific characteristics, such as improved strength, flexibility, or resistance to environmental factors.
Used in Organic Compound Synthesis:
5-(Hydroxymethyl)-1-methyl-1H-pyrazole is also used in the synthesis of various organic compounds. Its versatility in chemical reactions allows it to be a valuable building block in the creation of a wide range of organic molecules with diverse applications.
Used in Chemical Research:
5-(Hydroxymethyl)-1-methyl-1H-pyrazole is utilized in chemical research as a model compound for studying reaction mechanisms and exploring new synthetic pathways. Its unique properties make it an interesting subject for scientific investigation, potentially leading to new discoveries and advancements in the field of chemistry.

InChI:InChI=1/C5H8N2O/c1-7-5(4-8)2-3-6-7/h2-3,8H,4H2,1H3

Upstream product

• 84547-59-1 2-methyl-2H-pyrazole-3-carbonyl chloride 
• 27258-33-9 1-methyl-1H-pyrazole-5-carbaldehyde 
• 16034-46-1 1-methyl-1H-pyrazole-5-carboxylic acid 
• 17827-60-0 methyl 1-methyl-1H-pyrazole-5-carboxylate 
• 930-36-9 1-methyl-1H-pyrazole 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 497855-73-9 4-{[(1-methyl-1H-pyrazol-5-yl)methyl]sulfanyl}aniline 
• 1071814-23-7 2-(4-bromo-1-methyl-1H-pyrazol-5-yl)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}acetamide 
• 1071814-24-8 N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-2-(4-fluoro-1-methyl-1H-pyrazol-5-yl)acetamide 
• 1071814-22-6 2-(4-chloro-1-methyl-1H-pyrazol-5-yl)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}acetamide 
• 1071814-21-5 N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-2-(1-methyl-1H-pyrazol-5-yl)acetamide 
• 1071814-44-2 2-(1-methyl-1H-pyrazol-5-yl)acetic acid 
• 1607023-51-7 5-(3,4-dichlorophenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1607023-29-9 5-(4-fluoro-3-methoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1607023-28-8 5-(3-ethoxy-4-fluorophenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1607023-26-6 5-(4-chloro-3-isopropoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1071814-43-1 2-(1-methyl-1H-pyrazol-5-yl)acetonitrile 
• 1607023-01-7 5-(4-chloro-3-methoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 84547-63-7 5-(chloromethyl)-1-methyl-1H-pyrazole 
• 84547-71-7 1-methyl-5-(p-nitrostyryl)pyrazole 

Relevant academic research and scientific papers

Addressing the Metabolic Stability of Antituberculars through Machine Learning

We present the first prospective application of our mouse liver microsomal (MLM) stability Bayesian model. CD117, an antitubercular thienopyrimidine tool compound that suffers from metabolic instability (MLM t1/2 1/2 values greater than or equal to 60 min. It is noteworthy that whole-cell efficacy and lack of relative mammalian cell cytotoxicity could not be predicted simultaneously. These results support the utility of our new MLM stability model in chemical tool and drug discovery optimization efforts.

TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE

Provided are quinoline carboxamide and quinoline carbonitrile compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1, R 2, L, X 1, X 2, and X 3, are as defined herein. The compounds of the invention, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them, are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a person in need thereof for diseases or disorders in which the mGluR2-NAM receptor plays a causative role, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

PYRAZOLE DERIVATIVES AS P2X7 MODULATORS

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein R1 represents C1-6 alkyl or C3-6 cycloalkyl, either of which is optionally substituted with 1, 2 or 3 ha

Orally active CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological activities of 1-benzazepine derivatives containing a sulfoxide moiety

In order to develop orally active CCR5 antagonists, 1-propyl- or 1-isobutyl-1-benzazepine derivatives containing a sulfoxide moiety have been designed, synthesized, and evaluated for their biological activities. Sulfoxide compounds containing a 2-pyridyl

BENZAZEPINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE

The present invention provides a novel benzazepine derivative represented by formula : wherein, R1 is a 5- or 6-membered aromatic ring, R2 is lower alkyl group, etc., Y is an optionally substituted imino group, ring A and ring B are independently an optionally substituted aromatic ring, W is formula -W1-X2-W2- (W1 and W2 are independently S(O)m1 (m1 is 0, 1 or 2), etc., and X2 is an optionally substituted alkylene groupetc. ), a preparation method and use thereof.

Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapenems. Part IV. 2-Alkyl substituents containing cationic heteroaromatics linked via a C-C bond

The synthesis and biological activity of a novel series of 2-alkyl-4-pyrrolidinylthio-β-methylcarbapenems containing a variety of cationic heteroaromatic substituents linked via a C-C bond is described. As a result of these studies, we selected FR21818 (1

Studies on β-lactam antibiotics, synthesis and antibacterial activity of novel 1β-methylcarbapenems related to FR21818: 5-membered ring analogs

The synthesis and biological activity of the novel series of 1β-methylcarbapenems 1 are described. Most compounds displayed extremely potent antibacterial activity and high renal DHP-I stability. The best compound in this series, FR21818 (1a) displayed ex