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"Z-Ala-Lys(Mtr)-Lys(Mtr)-Leu-Leu-NH2" is a synthetic peptide consisting of six amino acids. It features a carbobenzoxy (Z) group protecting the N-terminus, which is crucial for preventing unwanted side reactions during peptide synthesis. The sequence includes two lysine (Lys) residues, each modified with a 4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) group, which serves as a photosensitive protecting group that can be cleaved upon exposure to light. This modification is particularly useful in applications such as photoaffinity labeling, where the peptide is designed to bind to a target protein and then be cleaved to reveal a reactive group that can form a covalent bond with the target. The peptide also contains two leucine (Leu) residues, which are hydrophobic amino acids that can influence the peptide's structure and interaction with other molecules. The C-terminus is capped with an amide group (NH2), which can affect the peptide's solubility and reactivity. This specific sequence and modification pattern suggest that "Z-Ala-Lys(Mtr)-Lys(Mtr)-Leu-Leu-NH2" is likely used in advanced biochemical research, such as studying protein-protein interactions or developing new therapeutic agents.

84552-28-3

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84552-28-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 84552-28-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,5,5 and 2 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 84552-28:
(7*8)+(6*4)+(5*5)+(4*5)+(3*2)+(2*2)+(1*8)=143
143 % 10 = 3
So 84552-28-3 is a valid CAS Registry Number.

84552-28-3Relevant academic research and scientific papers

4-Methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr): a New Amino and Imidazole Protecting Group in Peptide Synthesis

Wakimasu, Mitsuhiro,Kitada, Chieko,Fujino, Masahiko

, p. 2766 - 2779 (2007/10/02)

The 4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) group was introduced as a protecting group for the amino function, especially the ε-amino function of lysine, and the imidazole ring of histidine.The Nε-Mtr group was removable by dilute methanesulfonic acid-containing trifluoroacetic acid-thioanisole, but was stable to trifluoroacetic acid or catalytic hydrogenation.The Nim-Mtr group was removable by trifluoroacetic acid-dimethylsulfide or 1-hydroxybenzotriazole, but was more stable than the Nim-Tos or the Nim-Mbs group with triethylamine.To examine the usefulness of the Mtr group as a protecting group for use in peptide synthesis, mastoparan X and chicken gastrin releasing peptide (c-GRP) were synthesized, and this group was found to be very convenient for general solution synthesis.In particular, the introduction of Lys(Mtr) made possible a new strategy in peptide synthesis.Keywords-4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr); Nε-4-methoxy-2,3,6-trimethylbenzenesulfonyllysine; Nim-4-methoxy-2,3,6-trimethylbenzenesulfonylhistidine; methanesulfonic acid-trifluoroacetic acid-thioanisole deprotection; trifluoroacetic acid-dimethylsulfide deprotection; mastoparan X; chicken gastrin releasing peptide

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