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Z-Lys(Mtr)-Leu-Leu-NH2 is a synthetic peptide consisting of four amino acids: Z-protected lysine (Lys) with a 4-methoxytrityl (Mtr) group, leucine (Leu), and another leucine (Leu), followed by an amide group (NH2) at the C-terminus. This peptide is often used in research and drug development due to its specific sequence and protective group, which can influence its stability, solubility, and interaction with biological targets. The Mtr group is a common protecting group in peptide synthesis, used to prevent unwanted side reactions and ensure the correct sequence is formed during synthesis. The peptide's structure and properties make it a valuable tool for studying protein-protein interactions, enzyme substrate specificity, and as a potential therapeutic agent in various biomedical applications.

84553-17-3

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84553-17-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 84553-17-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,5,5 and 3 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 84553-17:
(7*8)+(6*4)+(5*5)+(4*5)+(3*3)+(2*1)+(1*7)=143
143 % 10 = 3
So 84553-17-3 is a valid CAS Registry Number.

84553-17-3Relevant academic research and scientific papers

4-Methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr): a New Amino and Imidazole Protecting Group in Peptide Synthesis

Wakimasu, Mitsuhiro,Kitada, Chieko,Fujino, Masahiko

, p. 2766 - 2779 (2007/10/02)

The 4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) group was introduced as a protecting group for the amino function, especially the ε-amino function of lysine, and the imidazole ring of histidine.The Nε-Mtr group was removable by dilute methanesulfonic acid-containing trifluoroacetic acid-thioanisole, but was stable to trifluoroacetic acid or catalytic hydrogenation.The Nim-Mtr group was removable by trifluoroacetic acid-dimethylsulfide or 1-hydroxybenzotriazole, but was more stable than the Nim-Tos or the Nim-Mbs group with triethylamine.To examine the usefulness of the Mtr group as a protecting group for use in peptide synthesis, mastoparan X and chicken gastrin releasing peptide (c-GRP) were synthesized, and this group was found to be very convenient for general solution synthesis.In particular, the introduction of Lys(Mtr) made possible a new strategy in peptide synthesis.Keywords-4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr); Nε-4-methoxy-2,3,6-trimethylbenzenesulfonyllysine; Nim-4-methoxy-2,3,6-trimethylbenzenesulfonylhistidine; methanesulfonic acid-trifluoroacetic acid-thioanisole deprotection; trifluoroacetic acid-dimethylsulfide deprotection; mastoparan X; chicken gastrin releasing peptide

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