84552-43-2

Upstream product

• 2304-96-3 N-benzyloxycarbonyl-L-asparagine 
• 84552-42-1 H-Trp-Lys(Mtr)-Gly-OBu^t 
• 83031-07-6 Z-Lys(Mtr)-OH 
• 83031-06-5 H-Lys(Mtr)-OH 
• 84552-41-0 Z-Trp-Lys(Mtr)-Gly-OBu^t 
• 84552-39-6 Z-Lys(Mtr)-Gly-OBu^t 
• 84552-40-9 H-Lys(Mtr)-Gly-OBu^t 
• 80745-07-9 4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride 
• 657-27-2 L-Lysine hydrochloride 
• 16881-32-6 tert-butyl N-(benzyloxycarbonyl)glycinate 
• 6456-74-2 Glycine tert-butyl ester 

Relevant academic research and scientific papers

4-Methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr): a New Amino and Imidazole Protecting Group in Peptide Synthesis

The 4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) group was introduced as a protecting group for the amino function, especially the ε-amino function of lysine, and the imidazole ring of histidine.The Nε-Mtr group was removable by dilute methanesulfonic acid-containing trifluoroacetic acid-thioanisole, but was stable to trifluoroacetic acid or catalytic hydrogenation.The Nim-Mtr group was removable by trifluoroacetic acid-dimethylsulfide or 1-hydroxybenzotriazole, but was more stable than the Nim-Tos or the Nim-Mbs group with triethylamine.To examine the usefulness of the Mtr group as a protecting group for use in peptide synthesis, mastoparan X and chicken gastrin releasing peptide (c-GRP) were synthesized, and this group was found to be very convenient for general solution synthesis.In particular, the introduction of Lys(Mtr) made possible a new strategy in peptide synthesis.Keywords-4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr); Nε-4-methoxy-2,3,6-trimethylbenzenesulfonyllysine; Nim-4-methoxy-2,3,6-trimethylbenzenesulfonylhistidine; methanesulfonic acid-trifluoroacetic acid-thioanisole deprotection; trifluoroacetic acid-dimethylsulfide deprotection; mastoparan X; chicken gastrin releasing peptide