845817-63-2

Upstream product

• 374937-38-9 but-2-ynyl-((R)-1-phenyl-ethyl)-amine 
• 4530-20-5 BOC-glycine 
• 845817-48-3 ({but-2-ynyl[(R)-1-phenylethyl]carbamoyl}methyl)carbamic acid tert-butyl ester 

Downstream Products

• 845817-49-4 2-amino-N-[(Z)-but-2-enyl]-N-[(R)-1-phenylethyl]acetamide 
• 845817-50-7 {(1S,2S)-2-methyl-1-[(R)-(1-phenylethyl)carbamoyl]but-3-enyl}carbamic acid benzyl ester 

Relevant academic research and scientific papers

Asymmetric total syntheses of marine cyclic depsipeptide halipeptins A-D

Halipeptins A-D (1a-d) are a family of natural cyclic depsipeptides isolated from marine sponges. Total syntheses of these four compounds are detailed in this report. The key elements in this synthesis include the elaboration of the polysubstituted decanoic acid parts by two asymmetric aldol reactions, assembly of the N-methyl-δ-hydroxyisoleucine residue by using either aza-Claisen rearrangement or methylation of aspartates as the key steps, and macrocyclization at the polysubstituted decanoic acid alanine site.