84594-78-5

Basic information

• Product Name: 6-Nitro-2,3-Dihydrobenzofuran-5-Amine
• Synonyms: 6-Nitro-2,3-Dihydrobenzofuran-5-Amine;6-nitro-2,3-dihydro-1-benzofuran-5-ylamine
• CAS NO: 84594-78-5
• Molecular Formula: C8H8N2O3
• Molecular Weight: 180.16072
• Mol File: 84594-78-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 148-149 °C(Solv: water (7732-18-5))
• Boiling Point: 370.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.456±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.21±0.20(Predicted)
• CAS DataBase Reference: 6-Nitro-2,3-Dihydrobenzofuran-5-Amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Nitro-2,3-Dihydrobenzofuran-5-Amine(84594-78-5)
• EPA Substance Registry System: 6-Nitro-2,3-Dihydrobenzofuran-5-Amine(84594-78-5)

Safety Data

• Hazardous Substances Data: 84594-78-5(Hazardous Substances Data)

Usage

General Description

6-Nitro-2,3-Dihydrobenzofuran-5-Amine is a chemical compound with the molecular formula C8H8N2O3. It is a yellow to orange solid that is soluble in organic solvents. 6-Nitro-2,3-Dihydrobenzofuran-5-Amine is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential antitumor and antiviral properties. Additionally, the nitro group in its structure makes it a versatile precursor for the synthesis of other important organic compounds. However, it is important to handle this chemical with caution as it can be toxic and harmful if ingested or inhaled.

Upstream product

• 7169-34-8 3-oxo-2,3-dihydrobenzo[b]furan 
• 81926-25-2 5-acetamido-2,3-dihydrobenzo<1,2-b>furan 
• 17403-47-3 5-nitro-2,3-dihydro-1-benzofuran 
• 42933-43-7 2,3-dihydro-1-benzofuran-5-amine 
• 496-16-2 2.3-dihydrobenzofuran 

Downstream Products

• 911300-51-1 6-nitro-2,3-dihydro-1-benzofuran 
• 1228880-71-4 5,6-diamino-2,3-dihydrobenzofuran 
• 57786-34-2 6-amino-2,3-dihydrobenzofuran 

Relevant articles and documents

Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain

In order to discover a novel type of analgesic, we investigated dual activity ligands with TRPV1 antagonism and mu-opioid receptor affinity with the goal of eliciting synergistic analgesia while avoiding the side effects associated with single targeting.

BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The present invention relates to benzimidazole derivatives and their pharmaceutical compositions and uses, specifically to benzimidazole derivatives of Formula (I), or their stereoisomer, pharmaceutically acceptable salt or solvates thereof, in which R1, R2, R3, R4, R5 and n have the definitions in the description; the present invention further relates to a pharmaceutical composition containing the compounds, methods for preparing the compounds, and use of the compounds for manufacturing of a medicament for prophylaxis and/or treatment of peptic ulcer, ulcer hemorrhage and diseases associated with gastric acid.

4' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, R5, R6, B, D, E, G, Q, x and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.