846543-19-9Relevant academic research and scientific papers
En route to the total synthesis of tashironin: On the exercise of stereochemical control by a methyl group in mediating remote cyclization reactions
Cook, Silas P.,Christoph, Gaul,Danishefsky, Samuel J.
, p. 843 - 847 (2007/10/03)
The synthesis of the [2.2.2]-bicyclic core (23) of the neurotrophic factor 11-O-debenzoyltashironin (1) has been achieved by an oxidative dearomatization-transannular Diels-Alder cascade. We have shown that the reaction sequence is also valuable for the efficient construction of related, complex [2.2.2]-bicyclic compounds (vide infra).
