84688-74-4

Basic information

• Product Name: 6-Chloro-N,N'-bis(3-chlorophenyl)-1,3,5-triazine-2,4-diamine
• Synonyms: 6-Chloro-N,N'-bis(3-chlorophenyl)-1,3,5-triazine-2,4-diamine;[4-chloro-6-[(3-chlorophenyl)amino]-s-triazin-2-yl]-(3-chlorophenyl)amine;AG-205/32381019;STK037411;ZINC00710838
• CAS NO: 84688-74-4
• Molecular Formula: C₁₅H₁₀Cl₃N₅
• Molecular Weight: 366.6324
• Mol File: 84688-74-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Chloro-N,N'-bis(3-chlorophenyl)-1,3,5-triazine-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-N,N'-bis(3-chlorophenyl)-1,3,5-triazine-2,4-diamine(84688-74-4)
• EPA Substance Registry System: 6-Chloro-N,N'-bis(3-chlorophenyl)-1,3,5-triazine-2,4-diamine(84688-74-4)

Safety Data

• Hazardous Substances Data: 84688-74-4(Hazardous Substances Data)

Usage

Type

Insecticide and acaricide

Physical properties

White powder, sparingly soluble in water, low volatility

Mode of action

Disrupts the nervous system of insects and mites, leading to paralysis and death

Application

Used to control pests in crops such as cotton, fruit trees, and vegetables

Regulation

Heavily regulated or banned in several countries due to potential toxicity and environmental impact.

Safety precautions

Important to handle and use with caution in accordance with safety guidelines

Upstream product

• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 108-42-9 3-chloro-aniline 
• 20376-34-5 4,6-dichloro-N-(3-chlorophenyl)-1,3,5-triazin-2-amine 

Downstream Products

• 84688-77-7 1-{4-[4,6-Bis-(3-chloro-phenylamino)-[1,3,5]triazin-2-ylamino]-phenyl}-ethanone 
• 21840-48-2 N²,N⁴,N⁶-tris-(3-chloro-phenyl)-[1,3,5]triazine-2,4,6-triyltriamine 
• 1425925-99-0 C₂₄H₁₇Cl₃N₆OS 
• 1425926-12-0 C₂₄H₁₇ClN₈O₅S 
• 1425926-05-1 C₂₄H₁₇ClF₂N₆OS 
• 1425926-09-5 C₂₄H₁₇ClN₈O₅S 
• 84688-90-4 C₂₉H₂₄Cl₂N₈O₃S 
• 76479-23-7 N,N'-Bis-(3-chloro-phenyl)-N''-[1-phenyl-meth-(E)-ylidene]-[1,3,5]triazine-2,4,6-triamine 
• 84688-95-9 4-[4,6-Bis-(3-chloro-phenylamino)-[1,3,5]triazin-2-ylamino]-benzoic acid methyl ester 

Relevant articles and documents

Discovery of novel 1,3,5-triazine-thiazolidine-2,4-diones as dipeptidyl peptidase-4 inhibitors with antibacterial activity targeting the S1 pocket for the treatment of type 2 diabetes

A novel series of 1,3,5-triazine-thiazolidine-2,4-diones was synthesized and characterized by a number of analytical and spectroscopic techniques. The molecules were screened for the in vitro inhibition of dipeptidyl peptidase-4 and compound 7a showed the most prominent inhibition with IC50 = 6.25 μM. The other compounds showed considerable inhibition (IC50 = 12.11-49.21 μM). Docking studies indicated that the lipophilic thiazolidine-2,4-dione fragment of ligand 7a was oriented towards the tight lipophilic cavity of the S1 pocket of the active site formed by residues such as Tyr631, Val656, Trp659, Tyr662, Tyr666 and Val711 via the formation of H-bonds with Tyr547. One of the amines present on the wings of the triazine formed a hydrogen bond with Glu205, a vital residue for the N-terminal recognition site with an efficient CDOCKER interaction energy. In a bacterial inhibition study, the entire set of compounds showed excellent activity and, in some instances, were found to be equipotent to the cefixime used as a standard.

Triaminotriazine DNA helicase inhibitors with antibacterial activity

Screening of a chemical library in a DNA helicase assay involving the Pseudomonas aeruginosa DnaB helicase provided a triaminotriazine inhibitor with good antibacterial activity but associated cytotoxicity toward mammalian cells. Synthesis of analogs provided a few inhibitors that retained antibacterial activity and demonstrated a significant reduction in cytotoxicity. The impact of serum and initial investigations toward a mode of action highlight several features of this class of compounds as antibacterials.

New varieties of crystalline architecture produced by small changes in molecular structure in tape complexes of melamines and barbiturates

This paper describes the crystal structures of a series of seven 1:1 complexes between N,N′-bis(m-X-phenyl)-melamine and 5,5-diethylbarbituric acid (X = H, F, Cl, Br, I, CH3, and CF3). This series provides small perturbations on the