84688-74-4

Usage

Type

Insecticide and acaricide

Physical properties

White powder, sparingly soluble in water, low volatility

Mode of action

Disrupts the nervous system of insects and mites, leading to paralysis and death

Application

Used to control pests in crops such as cotton, fruit trees, and vegetables

Regulation

Heavily regulated or banned in several countries due to potential toxicity and environmental impact.

Safety precautions

Important to handle and use with caution in accordance with safety guidelines

Upstream product

• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 108-42-9 3-chloro-aniline 
• 20376-34-5 4,6-dichloro-N-(3-chlorophenyl)-1,3,5-triazin-2-amine 

Downstream Products

• 1425926-09-5 C₂₄H₁₇ClN₈O₅S 
• 1425926-05-1 C₂₄H₁₇ClF₂N₆OS 
• 1425926-12-0 C₂₄H₁₇ClN₈O₅S 
• 1425925-99-0 C₂₄H₁₇Cl₃N₆OS 
• 84688-90-4 C₂₉H₂₄Cl₂N₈O₃S 
• 76479-23-7 N,N'-Bis-(3-chloro-phenyl)-N''-[1-phenyl-meth-(E)-ylidene]-[1,3,5]triazine-2,4,6-triamine 
• 21840-48-2 N²,N⁴,N⁶-tris-(3-chloro-phenyl)-[1,3,5]triazine-2,4,6-triyltriamine 
• 84688-95-9 4-[4,6-Bis-(3-chloro-phenylamino)-[1,3,5]triazin-2-ylamino]-benzoic acid methyl ester 
• 84688-77-7 1-{4-[4,6-Bis-(3-chloro-phenylamino)-[1,3,5]triazin-2-ylamino]-phenyl}-ethanone 

Relevant academic research and scientific papers

Discovery of novel 1,3,5-triazine-thiazolidine-2,4-diones as dipeptidyl peptidase-4 inhibitors with antibacterial activity targeting the S1 pocket for the treatment of type 2 diabetes

A novel series of 1,3,5-triazine-thiazolidine-2,4-diones was synthesized and characterized by a number of analytical and spectroscopic techniques. The molecules were screened for the in vitro inhibition of dipeptidyl peptidase-4 and compound 7a showed the most prominent inhibition with IC50 = 6.25 μM. The other compounds showed considerable inhibition (IC50 = 12.11-49.21 μM). Docking studies indicated that the lipophilic thiazolidine-2,4-dione fragment of ligand 7a was oriented towards the tight lipophilic cavity of the S1 pocket of the active site formed by residues such as Tyr631, Val656, Trp659, Tyr662, Tyr666 and Val711 via the formation of H-bonds with Tyr547. One of the amines present on the wings of the triazine formed a hydrogen bond with Glu205, a vital residue for the N-terminal recognition site with an efficient CDOCKER interaction energy. In a bacterial inhibition study, the entire set of compounds showed excellent activity and, in some instances, were found to be equipotent to the cefixime used as a standard.

Design and one-pot synthesis of hybrid thiazolidin-4-one-1,3,5-triazines as potent antibacterial agents against human disease-causing pathogens

An efficient and general one-pot reaction to a novel series of hybrid thiazolidine-4-one-1,3,5-triazine derivatives was developed. The easy work-up of the products, rapid reaction, and mild conditions are notable features of this protocol. These molecules were found to exhibit potent activity against a panel of Gram-positive and Gram-negative micro-organisms.

Triaminotriazine DNA helicase inhibitors with antibacterial activity

Screening of a chemical library in a DNA helicase assay involving the Pseudomonas aeruginosa DnaB helicase provided a triaminotriazine inhibitor with good antibacterial activity but associated cytotoxicity toward mammalian cells. Synthesis of analogs provided a few inhibitors that retained antibacterial activity and demonstrated a significant reduction in cytotoxicity. The impact of serum and initial investigations toward a mode of action highlight several features of this class of compounds as antibacterials.

Synthesis and biological evaluation of some new 3,4-dihydropyrimidin-4-ones

Condensation of 5-cyano-2-hydrazino-3-N-methyl-6-phenyl/p-chlorophenyl-3,4-dihydropyrimidin-4 -one (3a and 3b) with 2,4-bisalkyl/arylamino-6-chloro-s-triazine (4) gave the corresponding 2,4-bisalkyl/arylamino-6-[5′-cyano-3′-N-methyl]-6′-phenyl/p -chlorophenyl-3′,4′-dihydropyrimidin-4′-one-2′-yl-hyd razino-s-triazines (5a-n and 6a-n). The compounds 4 have been prepared by the condensation of cyanuric chloride and different alkyl/aryl amines. The reaction between 5-cyano-3-N-methyl-2-methylthio-6-phenyl/p-chlorophenyl-3,4-dihydropyrimidin- 4-one (2a and 2b) with hydrazine hydrate furnished 3a and 3b, respectively. The condensation of 6-phenyl/p-chlorophenyl/5-cyano-2-mercapto-3,4-dihydropyrimidin-4-one (1a and 1b) with methyl iodide yielded 2a and 2b, respectively. All the products have been evaluated in vitro for their antimicrobial activity against several microbes and antitubercular activity against Mycobacterium tuberculosis H37 Rv. Copyright

New varieties of crystalline architecture produced by small changes in molecular structure in tape complexes of melamines and barbiturates

This paper describes the crystal structures of a series of seven 1:1 complexes between N,N′-bis(m-X-phenyl)-melamine and 5,5-diethylbarbituric acid (X = H, F, Cl, Br, I, CH3, and CF3). This series provides small perturbations on the