84730-21-2

Upstream product

• 501-53-1 benzyl chloroformate 
• 84730-20-1 3,6-epimino-3,6-dideoxy-1,2-O-isopropylidene-α-D-glucofuranose 
• 84730-25-6 3,6-dideoxy-3,6-imino-1,2-O-isopropylidene-α-D-glucofuranose 
• 22169-72-8 3-azido-3-deoxy-6-O-toluene-p-sulphonyl-1,2-O-isopropylidene-α-D-glucofuranose 
• 22169-71-7 (R)-1-((3aR,5S,6S,6aR)-6-azido-2,2-dimethyltetrahydrofuro-[2,3-d][1,3]dioxol-5-yl)ethane-1,2-diol 
• 13964-23-3 3-azido-3-deoxy-1,2:5,6-di-(O-isopropylidene)-α-D-glucofuranose 
• 84730-21-2 3,6-<(benzyloxycarbonyl)imino>-3,6-dideoxy-1,2-O-isopropylidene-α-D-glucofuranose 
• 84730-22-3 3,6-(benzyloxycarbonyl)imino-3,6-dideoxy-1,2-O-isopropylidene-5-O-(methylsulfonyl)-α-D-glucofuranose 
• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 147429-00-3 Methanesulfonic acid (3aR,5R,6R,6aR)-5-((S)-2-bromo-1-hydroxy-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester 
• 2847-00-9 1,2:5,6-di-O-isopropylidene-α-D-hexofuran-3-ulose 
• 119403-65-5 6-azido-6-deoxy-1,2-O-isopropylidene-3-O-methanesulfonyl-α-D-allofuranose 
• 64993-88-0 1,2-O-isopropylidene-3-O-methanesulfonyl-α-D-allofuranose 
• 14728-80-4 1,2:5,6-di-O-isopropylidene-3-O-(methylsulphonyl)-α-D-allofuranose 

Downstream Products

• 860343-71-1 C₂₀H₂₇NO₆ 
• 860343-70-0 C₂₁H₂₃NO₅ 
• 84730-23-4 5-O-benzoyl-3,6-(benzyloxycarbonyl)imino-3,6-dideoxy-1,2-O-isopropylidene-β-L-idofuranose 
• 98237-83-3 1,2,5-tri-O-acetyl-3,6<(benzyloxycarbonyl)imino>-3,6-dideoxy-1,2-O-isopropylidene-D-glucofuranose 
• 119403-66-6 (3R,3aR,6S,6aS)-2,3,6-Trihydroxy-hexahydro-furo[3,2-b]pyrrole-4-carboxylic acid benzyl ester 
• 84730-22-3 3,6-(benzyloxycarbonyl)imino-3,6-dideoxy-1,2-O-isopropylidene-5-O-(methylsulfonyl)-α-D-glucofuranose 
• 114894-77-8 N-benzyloxycarbonyl-2-O-benzyl-1,4-dideoxy-1,4-imino-D-lyxitol 
• 143367-60-6 (S)-1-<(2R,3R)-3-acetoxy-1--2-pyrrolidinyl>-1-benzyloxy-3-<(tert-butyldimethylsilyl)oxy>-propane 
• 143367-59-3 (S)-1-<(2R,3R)-3-acetoxy-1-<(benzyloxy)carbonyl>-2-pyrrolidinyl>-1-benzyloxy-3-<(tert-butyldimethylsilyl)oxy>-propane 
• 143377-02-0 (3S)-3-benzyloxy-3-<(2S,3R)-1-<(benzyloxy)carbonyl>-3-hydroxy-2-pyrrolidinyl>-1-propanol 
• 98944-26-4 (-)-(2S,3R)-1-<(benzyloxy)carbonyl>-2-<(S)-1-(benzyloxy)prop-2-enyl>-3-hydroxypyrrolidine 

Relevant academic research and scientific papers

CYSTEINE PROTEASE INHIBITORS

Stereoisomers of the formula (III) wherein R is H or C1-C3 optionally halo-substituted alkyl; or pharmaceutically acceptable salts, hydrates or N-oxides thereof have utility in the treatment of disorders mediated by inappropriate exp

CYSTEINE PROTEASE INHIBITORS

A compound of the formula (II) wherein one of R1 and R2 is halo and the other is H or halo; R3 is -C1-C5 straight or branched chain, optionally fluorinated, alkyl or -CH2CR5Csub

BICYCLIC COMPOUNDS USEFUL AS CATHEPSIN S INBHIBITORS

Compounds of formula (I), wherein R1, R2, R3, Ra and E are are defined within, and pharmaceutically acceptable salts, solvates, hydrates and N-oxides thereof having utility in the treatment of disorders mediated by cathepsin S.

CYSTEINE PROTEASE INHIBITORS

A compound of the formula (II) wherein one of R1 and R2 is halo and the other is H or halo; R3 is C1-C4 straight or branched chain, optionally fluorinated, alkyl; R4 is H; or R3 together with R4 and the adjoining backbone carbon defines: a spiro-C5-C7 cycloalkyl, optionally substituted with 1 to 3 substituents selected from halo, hydroxyl, C1-C4 alkyl or C1-C4 haloalkyl; or optionally bridged with a methylene group; or a C4-C6 saturated heterocycle having a hetero atom selected from O, NRa, S, S(=O)2 ; where Ra is H, C1-C4 alkyl or CH3C(=O); R5 is independently selected from H or methyl; E is -C(=O)-, -S(=O)m-, -NR5S(=O)m-, -NR5C(=O)-, -OC(=O)-, R6 is a stable, optionally substituted, monocyclic or bicyclic, carbocycle or hetorocycle; m is independently 0,1 or 2; are inhibitors of cathepsin K and useful in the treatment or prophylaxis of osteoporosis.

Total synthesis of (+)-valyldetoxinine and (-)-detoxin D1

The detoxin complex, metabolites produced by Streptomyces caespitosus var. detoxicus 7072 GC1, is a selective antagonist of the antibiotic blasticidin S. Two approaches toward the total synthesis of (+)-valyldetoxinine and (-)-detoxin D1/

Total Synthesis of (-)-Detoxin D1

An efficient stereocontrolled total synthesis of (-)-detoxin D1, the most active component of the detoxin complex, is described.

SYNTHESIS OF (2R,3S,4R)-2-HYDROXYMETHYL-3,4-DIHYDROXYPYRROLIDINE HYDROCHLORIDE FROM D-GLUCOSE

(2R,3S,4R)-2-Hydroxymethyl-3,4-dihydroxypyrrolidine hydrochloride was synthesized from diacetone-D-glucose.

3,6-DIDEOXY-3,6-IMINO-1,2-O-ISODROPYLIDENE-α-D-GLUCOFURANOSE AS A DIVERGENT INTERMEDIATE FOR THE SYNTHESIS OF HYDROXYLATED PYRROLIDONES: SYNTHESIS IF 1,4-DIDEOXY-1,4-IMINO-L-GULITOL, 1,4-DIDEOXY-1,4-IMINO-D-LYXITOL, 2S,3S,4R,-3,4-DIHYDROXYPROLINE AND (1S,

An efficient synthesis of the p-toluenesulphonate salt of 3,6-dideoxy-3,6-imino-1,2-O-isopropylidene-α-D-glucofuranose (1) from glucose is reported; the potential of (1) in making hydroxylated pyrrolidines is illustrated by the preparation of 1,4-dideoxy-

Digitoxigenin 3-O-β-D-Furanosides

The syntheses of the title compounds were accomplished by Koenig-Knorr condensation of acylated furanoses with digitoxigenin followed by basic hydrolysis of protecting groups.In this manner the riboside, 5-amino-5-deoxyriboside, 3,6-anhydroglucoside, and