847448-41-3

Upstream product

• 847448-31-1 4-((R)-1-Azido-propyl)-1,2-difluoro-benzene 
• 847448-30-0 (S)-1-(3,4-Difluoro-phenyl)-propan-1-ol 
• 847448-32-2 (R)-1-(3,4-difluorophenyl)propylamine 
• 34036-07-2 3,4 difluorobenzaldehyde 

Relevant academic research and scientific papers

2-Mercaptoimidazoles, a new class of potent CCR2 antagonists

We describe the synthesis and SAR of a new class of CCR2 antagonists based on a 2-mercaptoimidazole scaffold. The initial lead 1a was optimized to the 3,4-disubstituted analogues 1p-(S) and 1q-(S), which have IC50 values in the MCP-1 induced Ca