847448-32-2

Usage

Uses

Used in Pharmaceutical Industry:
(R)-1-(3,4-Difluorophenyl)propan-1-aMine hydrochloride is used as a substrate for the enzyme ω-amidase, which plays a crucial role in the metabolism of fatty acids. This application is significant in the development of treatments for metabolic disorders and diseases related to fatty acid metabolism.
Used in Chemical Synthesis:
(R)-1-(3,4-Difluorophenyl)propan-1-aMine hydrochloride is utilized in the synthesis of pharmaceutical compounds, contributing to the creation of new drugs and therapeutic agents. Its unique structure and reactivity make it a valuable component in the development of novel medications.
Used as a Reagent in Chemical Reactions:
(R)-1-(3,4-Difluorophenyl)propan-1-aMine hydrochloride serves as a reagent in various chemical reactions, facilitating the synthesis of complex organic molecules and contributing to the advancement of chemical research and development.
Safety Precautions:
It is important to handle (R)-1-(3,4-Difluorophenyl)propan-1-aMine hydrochloride with care, as it can be harmful if ingested or inhaled and can cause skin and eye irritation. Proper safety measures, including the use of personal protective equipment and adherence to safety protocols, should be followed when working with (R)-1-(3,4-Difluorophenyl)propan-1-aMine hydrochloride to minimize potential risks.

Upstream product

• 34036-07-2 3,4 difluorobenzaldehyde 
• 847448-30-0 (S)-1-(3,4-Difluoro-phenyl)-propan-1-ol 
• 847448-31-1 4-((R)-1-Azido-propyl)-1,2-difluoro-benzene 

Downstream Products

• 847448-38-8 [(R)-1-(3,4-Difluoro-phenyl)-propylamino]-acetic acid methyl ester 
• 847448-41-3 {[(R)-1-(3,4-Difluoro-phenyl)-propyl]-formyl-amino}-acetic acid methyl ester 
• 1395077-35-6 2-((S)-2-hydroxy-1-methyl-ethylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(R)-1-(3,4-difluoro-phenyl)-propyl]-amide 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists

A series of 3,4- and 3,5-disubstituted phenyl-containing cyclobutenedione analogues were synthesized and evaluated as CXCR2 receptor antagonists. Variations in the disubstitution pattern of the phenyl ring afforded new compounds with potent CXCR2 binding

2-Mercaptoimidazoles, a new class of potent CCR2 antagonists

We describe the synthesis and SAR of a new class of CCR2 antagonists based on a 2-mercaptoimidazole scaffold. The initial lead 1a was optimized to the 3,4-disubstituted analogues 1p-(S) and 1q-(S), which have IC50 values in the MCP-1 induced Ca