847555-75-3 Usage
Uses
Used in Research Applications:
(S)-SHA 68 is used as a research tool for studying the roles of PRIP and GPRASP2 in cellular signaling and function. Its high selectivity for its target proteins makes it valuable for investigating the specific functions of PRIP and GPRASP2 in various biological processes.
Used in Cellular Signaling Pathway Studies:
(S)-SHA 68 is used as an inhibitor to study the functions of PRIP and GPRASP2 in cellular signaling pathways. Its lack of effect on other phospholipase C-related proteins makes it a specific tool for this purpose.
Used in Pharmaceutical Research:
(S)-SHA 68 may be used in the development of pharmaceuticals targeting PRIP and GPRASP2, given its high selectivity and potency as an inhibitor. This could potentially lead to the discovery of new therapeutic approaches for conditions related to the dysregulation of these proteins.
Check Digit Verification of cas no
The CAS Registry Mumber 847555-75-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,7,5,5 and 5 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 847555-75:
(8*8)+(7*4)+(6*7)+(5*5)+(4*5)+(3*5)+(2*7)+(1*5)=213
213 % 10 = 3
So 847555-75-3 is a valid CAS Registry Number.
847555-75-3Relevant academic research and scientific papers
Identification of neuropeptide s antagonists: Structure-Activity relationship studies, x-ray crystallography, and in vivo evaluation
Hassler, Carla,Zhang, Yanan,Gilmour, Brian,Graf, Tyler,Fennell, Timothy,Snyder, Rodney,Deschamps, Jeffrey R.,Reinscheid, Rainer K.,Garau, Celia,Runyon, Scott P.
, p. 731 - 744 (2014/11/08)
Modulation of the neuropeptide S (NPS) system has been linked to a variety of CNS disorders such as panic disorder, anxiety, sleeping disorders, asthma, obesity, PTSD, and substance abuse. In this study, a series of diphenyltetrahydro-1H-oxazolo[3,4-α]pyr
Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9 R/S)-3-Oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4- a ]pyrazine-7-carboxylic Acid 4-fluoro-benzylamide (SHA 68)
Trapella, Claudio,Pela, Michela,Del Zoppo, Luisa,Calo, Girolamo,Camarda, Valeria,Ruzza, Chiara,Cavazzini, Alberto,Costa, Valentina,Bertolasi, Valerio,Reinscheid, Rainer K.,Salvadori, Severo,Guerrini, Remo
, p. 2738 - 2744 (2011/06/27)
This study reports the synthesis, chromatographic separation, and pharmacological evaluation of the two enantiomers of the neuropeptide S receptor (NPSR) antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine- 7-carboxylic acid 4-fluoro-be
