1287264-37-2Relevant academic research and scientific papers
Synthesis of Enantiopure Piperazines via Asymmetric Lithiation-Trapping of N-Boc Piperazines: Unexpected Role of the Electrophile and Distal N-Substituent
Firth, James D.,O'Brien, Peter,Ferris, Leigh
, p. 651 - 659 (2016/01/29)
A new method for the synthesis of enantiopure α-substituted piperazines via direct functionalization of the intact piperazine ring is described. The approach utilizes the asymmetric lithiation-substitution of an α-methylbenzyl-functionalized N-Boc piperaz
Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9 R/S)-3-Oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4- a ]pyrazine-7-carboxylic Acid 4-fluoro-benzylamide (SHA 68)
Trapella, Claudio,Pela, Michela,Del Zoppo, Luisa,Calo, Girolamo,Camarda, Valeria,Ruzza, Chiara,Cavazzini, Alberto,Costa, Valentina,Bertolasi, Valerio,Reinscheid, Rainer K.,Salvadori, Severo,Guerrini, Remo
, p. 2738 - 2744 (2011/06/27)
This study reports the synthesis, chromatographic separation, and pharmacological evaluation of the two enantiomers of the neuropeptide S receptor (NPSR) antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine- 7-carboxylic acid 4-fluoro-be
